医药前沿
醫藥前沿
의약전연
YIAYAO QIANYAN
2015年
10期
134-135,136
,共3页
口腔鳞癌%树突状细胞%淋巴结转移
口腔鱗癌%樹突狀細胞%淋巴結轉移
구강린암%수돌상세포%림파결전이
Oral squamous-cell carcinoma (OSCC)%Dendritic cells(DCs) lymph nodes metastasis
目的：：研究口腔鳞癌组织（OSCC）中树突状细胞(DCs)的浸润密度的临床意义。方法：采用免疫组织化学染色S-P法检测S-100表达标记DCs，根据临床情况进行统计学分析。结果：OSCC中DCs浸润密度低于正常对照组（P=0.016），无转移组OSCC组织内DCs明显高于转移组，（P=0.010）。DCs浸润密度Ⅰ>Ⅱ>Ⅲ级，（P=0.030）。结论：DCs浸润密度与OSCC分化程度及转移关系密切， DCs在抑制肿瘤肿瘤发展、转移中起到一定的作用。
目的：：研究口腔鱗癌組織（OSCC）中樹突狀細胞(DCs)的浸潤密度的臨床意義。方法：採用免疫組織化學染色S-P法檢測S-100錶達標記DCs，根據臨床情況進行統計學分析。結果：OSCC中DCs浸潤密度低于正常對照組（P=0.016），無轉移組OSCC組織內DCs明顯高于轉移組，（P=0.010）。DCs浸潤密度Ⅰ>Ⅱ>Ⅲ級，（P=0.030）。結論：DCs浸潤密度與OSCC分化程度及轉移關繫密切， DCs在抑製腫瘤腫瘤髮展、轉移中起到一定的作用。
목적：：연구구강린암조직（OSCC）중수돌상세포(DCs)적침윤밀도적림상의의。방법：채용면역조직화학염색S-P법검측S-100표체표기DCs，근거림상정황진행통계학분석。결과：OSCC중DCs침윤밀도저우정상대조조（P=0.016），무전이조OSCC조직내DCs명현고우전이조，（P=0.010）。DCs침윤밀도Ⅰ>Ⅱ>Ⅲ급，（P=0.030）。결론：DCs침윤밀도여OSCC분화정도급전이관계밀절， DCs재억제종류종류발전、전이중기도일정적작용。
Objective To investigate dendritic cells(DCs) infiltration to assess their significances in the metastasis and prognosis in the oral squamous-cell carcinoma(OSCC).MethodsImmunohistochemistry S-P method was adopted to identify DCs infiltration, S-100 protein was used to mark DCs.Results DCs infiltration in normal oral mucosa were significantly higher in OSCC ( P = 0.016). The density of DCs in the group with lymph nodes metastasis was clearly lower than in the group with no lymph nodes metastasis in OSCC (P=0.010). The density of DCs were obviously decreased along differentiation of tumor,Ⅰ>Ⅱ>Ⅲ(P=0.030).Conclusion DCs infiltration was closely associated with tumor differentiation and lymph nodes metastasis, might inhibit the tumor progression and lymph nodes metastasis in OSCC.
