CAJ | 학술논문

目的：研究高敏C反应蛋白（hs‐CRP）在高血压阵发性心房颤动（AF）患者中应用的意义。方法选取2012年4月至2014年4月该院的高血压阵发性A F患者80例作为A F组，选取高血压无阵发性A F患者80例作为对照组。收集两组患者血浆hs‐CRP、全血高切黏度、全血低切黏度、血浆黏度、左室射血分数（LVEF）、左房内径（LA）、左室质量指数（LVMI），以及患者年龄、性别、高血压、瓣膜病、冠心病和孤立性房颤等一般数据，并进行统计学分析。对阵发性AF影响因素进行Logistic回归分析。结果两组患者年龄、性别、高血压、瓣膜病、冠心病和孤立性房颤、全血高切黏度、血浆黏度数据比较，差异无有统计学意义（P＞0．05）。两组患者全血低切黏度、LA、LVEF、LVMI数据比较，差异有统计学意义（P＜0．05）。Logistic回归分析显示，原发性高血压患者年龄越大、hs‐CRP对数值越大、左心肌越厚、左房越大出现阵发性AF的可能性越大。结论血浆hs‐CRP与高血压阵发性AF的发生关系密切。
목적：연구고민C반응단백（hs‐CRP）재고혈압진발성심방전동（AF）환자중응용적의의。방법선취2012년4월지2014년4월해원적고혈압진발성A F환자80례작위A F조，선취고혈압무진발성A F환자80례작위대조조。수집량조환자혈장hs‐CRP、전혈고절점도、전혈저절점도、혈장점도、좌실사혈분수（LVEF）、좌방내경（LA）、좌실질량지수（LVMI），이급환자년령、성별、고혈압、판막병、관심병화고립성방전등일반수거，병진행통계학분석。대진발성AF영향인소진행Logistic회귀분석。결과량조환자년령、성별、고혈압、판막병、관심병화고립성방전、전혈고절점도、혈장점도수거비교，차이무유통계학의의（P＞0．05）。량조환자전혈저절점도、LA、LVEF、LVMI수거비교，차이유통계학의의（P＜0．05）。Logistic회귀분석현시，원발성고혈압환자년령월대、hs‐CRP대수치월대、좌심기월후、좌방월대출현진발성AF적가능성월대。결론혈장hs‐CRP여고혈압진발성AF적발생관계밀절。
Objective To study the value of high‐sensitivity C‐reactive protein (hs‐CRP) in hypertension pa‐tients accompanied with paroxysmal atrial fibrillation (AF) .Methods A total of 80 hypertension patients with AF were selected from April 2012 to d April 2014 into AF group ,meanwhile 80 hypertension patients without AF were selected into control group .The levels of hs‐CRP ,whole blood high shear viscosity ,whole blood low shear viscosity , plasma viscosity ,left ventricular ejection fraction (LVEF) ,left atrial diameter (LA) ,left ventricular mass index (LV‐MI) ,as well as the patients′age ,gender ,hypertension ,valvular disease ,coronary heart disease and general data were analyzed .Logistic regression analysis was carried out on the factors affecting AF .Results The differences on age , gender ,hypertension ,valvular disease ,coronary heart disease and isolated AF ,whole blood high shear viscosity ,plas‐ma viscosity in the two groups were not statistical significant (P> 0 .05) .The differences on the whole blood low shear viscosity ,LA ,LVEF ,LVMI in the two groups was statistical significant (P<0 .05) .Logistic regression analy‐sis showed that the older the primary hypertension patients ,the higher the logarithms ,the thinker the left ventricu‐lar ,the higher the incidence rate of AF of left atrium .Conclusion The hs‐plasma CRP is closely related to the occur‐rence of AF in hypertension patients .