检验医学与临床
檢驗醫學與臨床
검험의학여림상
JOURNAL OF LABORATORY MEDICINE AND CLINICAL SCIENCES
2015年
10期
1393-1394
,共2页
慢性阻碍性肺病急性加重%肺心病%N末端脑B型钠肽前体
慢性阻礙性肺病急性加重%肺心病%N末耑腦B型鈉肽前體
만성조애성폐병급성가중%폐심병%N말단뇌B형납태전체
acute exacerbation stage of chronic obstructive pulmonary disease%cor pulmonale%amino-ter-minal pro-brain natriuretic peptide
目的：探讨N末端B型脑钠肽前体（NT‐proBNP）在慢性阻碍性肺病急性加重期（AECOPD）合并肺心病（CP）诊断中的临床意义。方法选择2013年9月至2014年5月该院收治的单纯COPD患者32例为COPD组，AECOPD患者30例为AECOPD组，AECOPD合并CP组患者36例为合并组。分别测定各组血清NT‐proBNP水平。比较各组间差异，并绘制受试者操作特性曲线。结果 COPD组血清NT‐proBNP水平为（369．21±95．46） pg／mL ，AECOPD组为（571．71±209．92）pg／mL ，合并组为（4640．53±559．54）pg／mL。COPD组与 AECOPD组比较，差异无统计学意义（P＞0．05），合并组患者血清 NT‐proBNP水平较其他两组高，差异有统计学意义（P＜0．05）。合并组血清NT‐proBNP水平曲线显示，NT‐proBNP取1093 pg／mL 时，敏感度和特异性分别为97％和87％。结论血清NT‐proBNP检测对AECOPD合并CP的诊断具有重要意义。
目的：探討N末耑B型腦鈉肽前體（NT‐proBNP）在慢性阻礙性肺病急性加重期（AECOPD）閤併肺心病（CP）診斷中的臨床意義。方法選擇2013年9月至2014年5月該院收治的單純COPD患者32例為COPD組，AECOPD患者30例為AECOPD組，AECOPD閤併CP組患者36例為閤併組。分彆測定各組血清NT‐proBNP水平。比較各組間差異，併繪製受試者操作特性麯線。結果 COPD組血清NT‐proBNP水平為（369．21±95．46） pg／mL ，AECOPD組為（571．71±209．92）pg／mL ，閤併組為（4640．53±559．54）pg／mL。COPD組與 AECOPD組比較，差異無統計學意義（P＞0．05），閤併組患者血清 NT‐proBNP水平較其他兩組高，差異有統計學意義（P＜0．05）。閤併組血清NT‐proBNP水平麯線顯示，NT‐proBNP取1093 pg／mL 時，敏感度和特異性分彆為97％和87％。結論血清NT‐proBNP檢測對AECOPD閤併CP的診斷具有重要意義。
목적：탐토N말단B형뇌납태전체（NT‐proBNP）재만성조애성폐병급성가중기（AECOPD）합병폐심병（CP）진단중적림상의의。방법선택2013년9월지2014년5월해원수치적단순COPD환자32례위COPD조，AECOPD환자30례위AECOPD조，AECOPD합병CP조환자36례위합병조。분별측정각조혈청NT‐proBNP수평。비교각조간차이，병회제수시자조작특성곡선。결과 COPD조혈청NT‐proBNP수평위（369．21±95．46） pg／mL ，AECOPD조위（571．71±209．92）pg／mL ，합병조위（4640．53±559．54）pg／mL。COPD조여 AECOPD조비교，차이무통계학의의（P＞0．05），합병조환자혈청 NT‐proBNP수평교기타량조고，차이유통계학의의（P＜0．05）。합병조혈청NT‐proBNP수평곡선현시，NT‐proBNP취1093 pg／mL 시，민감도화특이성분별위97％화87％。결론혈청NT‐proBNP검측대AECOPD합병CP적진단구유중요의의。
Objective To investigate the clinical significance of amino‐terminal pro‐brain natriuretic peptide (NT‐proBNP)detection in acute exacerbations stage of chronic obstructive pulmonary disease (AECOPD) accompa‐nied with cor pulmonale (CP) in the elderly .Methods A total of 32 patients only with chronic obstructive pulmonary disease(COPD) were assigned into COPD group ,30 patients with AECOPD were recruited into AECOPD group ,and 36 patients with AECOPD accompanied with CP were recruited into AECOPD +CP group .The serum NT‐proBNP levels were detected and compa red in the three groups ,and the receiver operating characteristic (ROC) curves were plotted .Results Serum NT‐proBNP levels in the COPD ,AECOPD and AECOPD + CP group were (369 .21 ± 95 .46) ,(571 .71 ± 209 .92) ,(4 640 .53 ± 559 .54)pg/mL respectively .The difference between COPD group and AE‐COPD group was not statistical significant (P>0 .05) ,the serum NT‐proBNP level in the AECOPD+CP group was higher than that in the other two groups ,the difference was statistical significant (P<0 .05) .The ROC curve of the serum NT‐proBNP level of the AECOPD+CP group showed that while the NT‐proBNP level was 1 093 pg/mL ,the sensitivity and specificity were 97% and 87% respectively .Conclusion Detection of serum NT‐proBNP has profound significance to diagnosis for AECOPD accompanied with CP .
