微循环学杂志
微循環學雜誌
미순배학잡지
CHINESE JOURNAL OF MICROCIRCULATION
2015年
2期
44-48
,共5页
白细胞介素 1 0%结核病%单核苷酸多态性%Meta分析
白細胞介素 1 0%結覈病%單覈苷痠多態性%Meta分析
백세포개소 1 0%결핵병%단핵감산다태성%Meta분석
Interleukin 10%Tuberculosis%Single nucleotides polymorphism%Meta-analysis
目的：：研究白细胞介素-10-1082G/A基因位点多态性与结核病易感性的关系。方法：利用 PubMed、Medline、EMbase等数据库检索相关文献。采用筛选标准和方法学质量评价,纳入符合要求的文献,并采用 Stata 12.0软件进行 Meta分析,计算合并 OR值及其95% CI,最后进行敏感性分析及发表偏倚评估。结果：共26篇文献纳入研究,其中病例组(结核病患者)5949例,对照组(健康体检者)6948例。Meta 分析结果显示,在各个遗传模型中,IL-10-1082G/A基因多态性与结核病总体发病风险关系不大。对纳入研究以种族为分层因素进行分析,在欧洲人群中 GG纯合子基因型者结核病发病率高于 AG+AA基因型者(OR=1.69,95% CI=1.19-2.39,P<0.05)。对纳入研究以疾病类型为分层因素进行分析,GG纯合子基因型者肺结核与肺外结核发病率高于 AA纯合子基因型者(OR=2.00,95% CI=1.16-3.45,P<0.05)。经Begg’s与 Egger’s 检验,纳入的所有研究未见明显发表偏倚。结论：IL-10-1082G/A基因多态性中等位基因 G可能与结核病易感性风险增高相关,这种情况可能只存在于欧洲人群及混合结核病中。
目的：：研究白細胞介素-10-1082G/A基因位點多態性與結覈病易感性的關繫。方法：利用 PubMed、Medline、EMbase等數據庫檢索相關文獻。採用篩選標準和方法學質量評價,納入符閤要求的文獻,併採用 Stata 12.0軟件進行 Meta分析,計算閤併 OR值及其95% CI,最後進行敏感性分析及髮錶偏倚評估。結果：共26篇文獻納入研究,其中病例組(結覈病患者)5949例,對照組(健康體檢者)6948例。Meta 分析結果顯示,在各箇遺傳模型中,IL-10-1082G/A基因多態性與結覈病總體髮病風險關繫不大。對納入研究以種族為分層因素進行分析,在歐洲人群中 GG純閤子基因型者結覈病髮病率高于 AG+AA基因型者(OR=1.69,95% CI=1.19-2.39,P<0.05)。對納入研究以疾病類型為分層因素進行分析,GG純閤子基因型者肺結覈與肺外結覈髮病率高于 AA純閤子基因型者(OR=2.00,95% CI=1.16-3.45,P<0.05)。經Begg’s與 Egger’s 檢驗,納入的所有研究未見明顯髮錶偏倚。結論：IL-10-1082G/A基因多態性中等位基因 G可能與結覈病易感性風險增高相關,這種情況可能隻存在于歐洲人群及混閤結覈病中。
목적：：연구백세포개소-10-1082G/A기인위점다태성여결핵병역감성적관계。방법：이용 PubMed、Medline、EMbase등수거고검색상관문헌。채용사선표준화방법학질량평개,납입부합요구적문헌,병채용 Stata 12.0연건진행 Meta분석,계산합병 OR치급기95% CI,최후진행민감성분석급발표편의평고。결과：공26편문헌납입연구,기중병례조(결핵병환자)5949례,대조조(건강체검자)6948례。Meta 분석결과현시,재각개유전모형중,IL-10-1082G/A기인다태성여결핵병총체발병풍험관계불대。대납입연구이충족위분층인소진행분석,재구주인군중 GG순합자기인형자결핵병발병솔고우 AG+AA기인형자(OR=1.69,95% CI=1.19-2.39,P<0.05)。대납입연구이질병류형위분층인소진행분석,GG순합자기인형자폐결핵여폐외결핵발병솔고우 AA순합자기인형자(OR=2.00,95% CI=1.16-3.45,P<0.05)。경Begg’s여 Egger’s 검험,납입적소유연구미견명현발표편의。결론：IL-10-1082G/A기인다태성중등위기인 G가능여결핵병역감성풍험증고상관,저충정황가능지존재우구주인군급혼합결핵병중。
Objective:To investigate the association between interleukin-10 (IL-10)gene promoter SNP -1082G/A polymorphism and tuberculosis(TB)susceptibility.Method:Such databases as PubMed,Medline and EM-base data were searched to collect the case-control studies published.According to the inclusion and exclusion crite-ria,the studies were screened,the data were extracted,and the methodological quality of the included studies was e-valuated.Then meta-analysis was conducted using Stata 12.0 software,the pooled odds ratio (ORs)with 95%conidence interval (CI)were calculated,and the sensitivity and publication bias were evaluated at the same time.Re-sults:A total of 26 studies were included,which involved 5 949 cases and 6 948 healthy controls.The results of me-ta-analysis showed that,the IL-10-1082G/A polymorphism had no association with a increased risk of TB.In the stratified analysis by ethnicity,significantly increased risk of TB was associated with Asians in IL-10-1082G/A polymorphism (GG vs AG+AA:OR=1.69,95% CI=1.19-2.39,P<0.05).We also performed the analyses by desease types in IL-10-1082A/G polymorphism,significant increased TB risk was observed in mixed group under homozygous model (GG vs AA:OR=2.00,95% CI= 1.16-3.45,P<0.05).All of the included studies showed no publication bias by Begg's and Egger's test.Conclusion:The results suggested that the IL-10-1082G/A polymor-phism was associated with TB increased risk in Europeans and mixed tuberculesic.
