CAJ | 학술논문

目的：：观察抗血小板药物氯吡格雷对高血压大鼠微循环的影响。方法：SPF级雄性13周龄自发性高血压大鼠(SHR),随机分为溶剂对照组和氯吡格雷组,每组5只,分别灌胃1ml 0.5%羧甲基纤维素钠(CMC-Na)和氯吡格雷溶液(10mg/kg),每日一次。连续四周后,用高功率激光多普勒血流探测仪(LDF)检测大鼠脑皮质、耳廓及趾血流量、血细胞聚集度和血流速度,用血流成像仪(LDPI)观察脑血流分布状态。统计学分析检测指标的组间差异。结果：除血细胞聚集度和脑皮质血流速度外,氯吡格雷组大鼠上述 LDF检测指标值均高于溶剂对照组(P<0.05或P<0.01),LDPI检测脑皮质血流分布曲线整体右移,脑皮质高血流量(800-1500PU)面积百分比较溶剂对照组明显增加(P<0.01)。结论：氯吡格雷可明显改善 SHR微循环障碍。
목적：：관찰항혈소판약물록필격뢰대고혈압대서미순배적영향。방법：SPF급웅성13주령자발성고혈압대서(SHR),수궤분위용제대조조화록필격뢰조,매조5지,분별관위1ml 0.5%최갑기섬유소납(CMC-Na)화록필격뢰용액(10mg/kg),매일일차。련속사주후,용고공솔격광다보륵혈류탐측의(LDF)검측대서뇌피질、이곽급지혈류량、혈세포취집도화혈류속도,용혈류성상의(LDPI)관찰뇌혈류분포상태。통계학분석검측지표적조간차이。결과：제혈세포취집도화뇌피질혈류속도외,록필격뢰조대서상술 LDF검측지표치균고우용제대조조(P<0.05혹P<0.01),LDPI검측뇌피질혈류분포곡선정체우이,뇌피질고혈류량(800-1500PU)면적백분비교용제대조조명현증가(P<0.01)。결론：록필격뢰가명현개선 SHR미순배장애。
Objective:To observe the effect of antiplatelet drug(Clopidogrel)on the microcirculation of Spon-taneous Hypertensive Rat(SHR).Method:Two groups of 13-week-old male SHRs were studied with 5 rats in each group:placebo control and clopidogrel (10mg/kg).Drugs therapy was administered by oral perfusion for 4 weeks continuously.The blood flow,blood flow velocity,blood cell aggregation and whole distribution curve of blood flow of SHR's cerebral cortices,auricles and toes were detected by the high power Laser Doppler flowmetry and the Laser Doppler Perfusion Imaging.Results:In SHR treated with clopidogrel,the above indexes were significantly increased comparing with placebo control group(P<0.05 or P<0.01)except blood cell aggregation and blood flow of cerebral cortices.The whole distribution curve of blood flow moved to the right and the high blood flow of cerebral cortices (800-1500PU)was obviously increased comparing with placebo control group(P<0.01).Conclusion:Clopidogrel can improve the SHR’s microcirculation.