CAJ | 학술논문

目的：：探讨麻醉前应用新型抗胆碱药物长托宁(盐酸戊乙奎醚)对失血大鼠肠系膜微循环改变的影响。方法：4月龄 SD大鼠14只，随机分为长托宁组和对照组(n均=7)，分别于5%水合氯醛麻醉前腹腔注射长托宁和生理盐水(0.17ml/100g)，麻醉30min后行颈总动脉插管及腹腔侧切口暴露肠系膜，放血前和放血至动脉压恒定于60mmHg时观测两组大鼠肠系膜微血管口径及血液流速，统计学分析比较组间微血管收缩率和微血流速度。结果：失血可致肠系膜微血管显著收缩，血流速度明显减慢，长托宁组大鼠微血管收缩率及血液流速减缓率均明显低于对照组(P<0.05)。结论：麻醉前长托宁干预能有效改善大鼠失血性肠系膜微循环障碍。
목적：：탐토마취전응용신형항담감약물장탁저(염산무을규미)대실혈대서장계막미순배개변적영향。방법：4월령 SD대서14지，수궤분위장탁저조화대조조(n균=7)，분별우5%수합록철마취전복강주사장탁저화생리염수(0.17ml/100g)，마취30min후행경총동맥삽관급복강측절구폭로장계막，방혈전화방혈지동맥압항정우60mmHg시관측량조대서장계막미혈관구경급혈액류속，통계학분석비교조간미혈관수축솔화미혈류속도。결과：실혈가치장계막미혈관현저수축，혈류속도명현감만，장탁저조대서미혈관수축솔급혈액류속감완솔균명현저우대조조(P<0.05)。결론：마취전장탁저간예능유효개선대서실혈성장계막미순배장애。
Objective:To explore the effect of a new anticholinergic drug penehyclidine hydrochloride used as preanesthetic medication on mesenteric microcirculation of rats during bleeding.Method:Fourteen SD rats (4 months)were divided into penehyclidine group and control group.Before the general anesthesia with 5% chloral hy-drate,0.17ml/100g of normal saline or penehyclidine hydrochloride was peritoneally injected into the rats.Thirty minutes after the general anesthesia,carotid-arterial-intubation surgery was performed and mesenteric microcircula-tion was exposed and observed under the microscope.The diameters of mesenteric microvessels,the blood flow ve-locity and status were recorded before and after bloodletting until blood pressure decreased to 60 mmHg.The con-traction rate of the microvessels and reduction rate of the blood flow velocity were calculated and compared statisti-cally.Results:Hemorrhage resulted in significant vasoconstriction of the mesenteric microvessels and decreased blood flow velocity.Penehyclidine hydrochloride injection before anesthesia significantly attenuated these changes (P<0. 05).Conclusion:Penehyclidine hydrochloride used as preanesthetic medication could improve mesenteric microcircu-lation during bleeding in rats.