CAJ | 학술논문

生理状态下,自由基对细胞生命活动起着重要作用.当机体受到有害刺激导致氧化应激时,自由基产生增多或清除减少,造成细胞及组织的氧化损伤.糖尿病性白内障是糖尿病的并发症之一,目前认为其发病机制包括多元醇通路的激活、氧化应激和晶状体蛋白的非酶糖基化等三种假说,其中氧化应激作用作为中心环节备受关注,其与糖尿病性白内障的发生密切相关.酶促和非酶促防御抗氧化系统的开发应用为白内障防治提供了一种策略,为缓解和预防糖尿病性白内障的研究提供了新思路.
생리상태하,자유기대세포생명활동기착중요작용.당궤체수도유해자격도치양화응격시,자유기산생증다혹청제감소,조성세포급조직적양화손상.당뇨병성백내장시당뇨병적병발증지일,목전인위기발병궤제포괄다원순통로적격활、양화응격화정상체단백적비매당기화등삼충가설,기중양화응격작용작위중심배절비수관주,기여당뇨병성백내장적발생밀절상관.매촉화비매촉방어항양화계통적개발응용위백내장방치제공료일충책략,위완해화예방당뇨병성백내장적연구제공료신사로.
Under physiological conditions,radicals on cellular activities play an important role.When the body is subjected to noxious stimuli lead to oxidative stress,the increased production or decreased removal of radicals result in oxidative damage to cells and tissues.Diabetic cataract is one of the complications of diabetes,and an important class of blinding eye disease.Currently its pathological mechanisms were considered including polyol pathway activation,oxidative stress and non-enzymatic glycation of lens proteins.Oxidative stress action as a central part is attractive,which is closely related to the generation of diabetic cataract.The development of nzymatic and non-enzymatic antioxidant defense systems provides a strategy for anti-cataract,and provides a new idea for mitigation and prevention of diabetic cataract studies.