河北医学
河北醫學
하북의학
HEBEI MEDICINE
2015年
10期
1641-1645
,共5页
帕金森病%脑动脉硬化%认知功能%经颅多普勒
帕金森病%腦動脈硬化%認知功能%經顱多普勒
파금삼병%뇌동맥경화%인지공능%경로다보륵
Parkinson disease%Cerebral arteriosclerosis%Cognitive function%Transcranial doppler
目的：探讨经颅超声多普勒（ TCD）对原发性帕金森病脑动脉硬化的评价价值及其与患者认知功能障碍的相关性研究。方法：选择2011年1月至2013年6月神经内科和帕金森专病门诊诊治的原发性帕金森病患者158例作为研究组，所有患者行经颅多普勒超声检查以评定脑动脉硬化情况，并选择同期体检健康人60例作为对照组。应用蒙特利尔认知评估量表（ MoCA ）测试两组认知功能。结果：研究组中患者伴脑动脉硬化64例，占40．5％。帕金森伴脑动脉硬化组MCA和BA PI、RI显著高于帕金森不伴脑动脉硬化组和对照组， Vm、Vd显著低于帕金森不伴脑动脉硬化组和对照组（ P＜0．05）。帕金森伴脑动脉硬化组、帕金森不伴脑动脉硬化组MoCA各项得分及总分显著低于对照组，帕金森伴脑动脉硬化组MoCA各项得分及总分显著低于帕金森不伴脑动脉硬化组（ P＜0．05）。相关性分析显示MoCA总分与大脑基底动脉（BA）、大脑中动脉（MCA）搏动指数（PI）、阻力指数（RI）呈负相关（r＝－0．354，－0．276，－0．307，－0．235，均P＜0．05）。结论：帕金森病患者认知功能障碍与脑动脉硬化有密切的关系，通过TCD评价患者脑动脉硬化情况对原发性帕金森病认知功能障碍诊断具有一定价值。
目的：探討經顱超聲多普勒（ TCD）對原髮性帕金森病腦動脈硬化的評價價值及其與患者認知功能障礙的相關性研究。方法：選擇2011年1月至2013年6月神經內科和帕金森專病門診診治的原髮性帕金森病患者158例作為研究組，所有患者行經顱多普勒超聲檢查以評定腦動脈硬化情況，併選擇同期體檢健康人60例作為對照組。應用矇特利爾認知評估量錶（ MoCA ）測試兩組認知功能。結果：研究組中患者伴腦動脈硬化64例，佔40．5％。帕金森伴腦動脈硬化組MCA和BA PI、RI顯著高于帕金森不伴腦動脈硬化組和對照組， Vm、Vd顯著低于帕金森不伴腦動脈硬化組和對照組（ P＜0．05）。帕金森伴腦動脈硬化組、帕金森不伴腦動脈硬化組MoCA各項得分及總分顯著低于對照組，帕金森伴腦動脈硬化組MoCA各項得分及總分顯著低于帕金森不伴腦動脈硬化組（ P＜0．05）。相關性分析顯示MoCA總分與大腦基底動脈（BA）、大腦中動脈（MCA）搏動指數（PI）、阻力指數（RI）呈負相關（r＝－0．354，－0．276，－0．307，－0．235，均P＜0．05）。結論：帕金森病患者認知功能障礙與腦動脈硬化有密切的關繫，通過TCD評價患者腦動脈硬化情況對原髮性帕金森病認知功能障礙診斷具有一定價值。
목적：탐토경로초성다보륵（ TCD）대원발성파금삼병뇌동맥경화적평개개치급기여환자인지공능장애적상관성연구。방법：선택2011년1월지2013년6월신경내과화파금삼전병문진진치적원발성파금삼병환자158례작위연구조，소유환자행경로다보륵초성검사이평정뇌동맥경화정황，병선택동기체검건강인60례작위대조조。응용몽특리이인지평고량표（ MoCA ）측시량조인지공능。결과：연구조중환자반뇌동맥경화64례，점40．5％。파금삼반뇌동맥경화조MCA화BA PI、RI현저고우파금삼불반뇌동맥경화조화대조조， Vm、Vd현저저우파금삼불반뇌동맥경화조화대조조（ P＜0．05）。파금삼반뇌동맥경화조、파금삼불반뇌동맥경화조MoCA각항득분급총분현저저우대조조，파금삼반뇌동맥경화조MoCA각항득분급총분현저저우파금삼불반뇌동맥경화조（ P＜0．05）。상관성분석현시MoCA총분여대뇌기저동맥（BA）、대뇌중동맥（MCA）박동지수（PI）、조력지수（RI）정부상관（r＝－0．354，－0．276，－0．307，－0．235，균P＜0．05）。결론：파금삼병환자인지공능장애여뇌동맥경화유밀절적관계，통과TCD평개환자뇌동맥경화정황대원발성파금삼병인지공능장애진단구유일정개치。
Objective:To investigate the relationship between primary cerebral arteriosclerosis in Par-kinson disease and cognitive impairment in patients with transcranial doppler ultrasonography .Method:Se-lected 158 cases of idiopathic Parkinson's disease from 2011 January to 2013 June in our hospital as the stud-y group, all the patients underwent transcranial Doppler ultrasound to assess cerebral arteriosclerosis , and 60 cases of healthy people were selected as the control group .Applied Montreal cognitive assessment scale ( Mo-CA) to test cognitive function .Result:There were 64 cases cerebral arteriosclerosis in study group , account-ing for 40.5%.Parkinson with cerebral arteriosclerosis group MCA and BA PI , RI were significantly higher than that of Parkinson without cerebral artery atherosclerosis group and the control group , Vm, Vd were sig-nificantly lower than Parkinson without cerebral artery atherosclerosis group and the control group ( P<0.05) . Parkinson, Parkinson with cerebral arteriosclerosis group without cerebral arteriosclerosis group MoCA each score and total score was significantly lower than the control group , the Parkinson with cerebral arteriosclero-sis group MoCA each score and total score were significantly lower than those of Parkinson without cerebral artery atherosclerosis group ( P<0.05) .Correlation analysis showed that MoCA score and cerebral basilar ar-tery (BA), middle cerebral artery (MCA) pulsatility index (PI), resistance index (RI) showed a negative correlation (r=-0.354,-0.276,-0.307,-0.235, P<0.05).Conclusion:There is a close relationship be-tween the cognitive dysfunction and Parkinson disease patients with cerebral arteriosclerosis , as assessed by TCD in patients with cerebral arteriosclerosis of primary cognitive impairment in Parkinson's disease diagnosis has the certain value .
