CAJ | 학술논문

目的：研究美长安联合曲美布汀或和赛乐特治疗腹泻型肠易激综合征（ Irritable bowel syndrome，IBS）的随机对照性情况，为临床治疗腹泻型IBS选择合适方案。方法：选择2010年1月至2013年12月接受治疗的腹泻型IBS患者191例作为研究对象。根据随机数字法对患者进行分组，其中A组（美长安）46例，B组（美长安＋曲美布汀）51例，C组（美长安＋赛乐特）45例，D组（美长安＋曲美布汀＋赛乐特）49例。分别对各组进行药物治疗，3周后对比各组整体疗效情况以及治疗前后单项症状情况。结果：B组、C组和D组的总有效率均显著高于A组，D组的总有效率显著高于B组和C组，差异均有统计学意义（均P＜0．05）。治疗后B组、C组和D组的排便次数、大便性状以及腹痛情况症状分值均显著低于A组；同时，D组的排便次数、大便性状以及腹痛情况症状分值显著低于B组和C组，差异均有统计学意义（均P＜0．05）。结论：采用美长安联合曲美布汀及赛乐特治疗中重度的IBS患者可获得较好疗效，对于症状轻微者则可尝试美长安二联疗法，值得重视。
목적：연구미장안연합곡미포정혹화새악특치료복사형장역격종합정（ Irritable bowel syndrome，IBS）적수궤대조성정황，위림상치료복사형IBS선택합괄방안。방법：선택2010년1월지2013년12월접수치료적복사형IBS환자191례작위연구대상。근거수궤수자법대환자진행분조，기중A조（미장안）46례，B조（미장안＋곡미포정）51례，C조（미장안＋새악특）45례，D조（미장안＋곡미포정＋새악특）49례。분별대각조진행약물치료，3주후대비각조정체료효정황이급치료전후단항증상정황。결과：B조、C조화D조적총유효솔균현저고우A조，D조적총유효솔현저고우B조화C조，차이균유통계학의의（균P＜0．05）。치료후B조、C조화D조적배편차수、대편성상이급복통정황증상분치균현저저우A조；동시，D조적배편차수、대편성상이급복통정황증상분치현저저우B조화C조，차이균유통계학의의（균P＜0．05）。결론：채용미장안연합곡미포정급새악특치료중중도적IBS환자가획득교호료효，대우증상경미자칙가상시미장안이련요법，치득중시。
Objective:To study live combined bacillus subtilis and enterococcus faecium enteric-coated capsules combined with trimebutine maleate tablets or/and paroxetine hydrochloride tablets in the treatment of irritable bowel syndrome ( IBS) , to provide appropriate solutions for the clinical treatment of diarrhea type of IBS.Methods:From Jan.2010 to Dec.2010 in our hospital, 191 cases of diarrhea type of IBS patients were as the research object .They're divided intofour groups according to random number method , group A had 46 cases, group B had 51 cases, group C had 45 cases, and group D had 49 cases.Each group was giv-en drug to treat respectively , three weeks after treatment , compared between groups with curative effect and the individual symptoms before and after the treatment .Result:Total effective rate of group B and group C and group D were significantly higher than group A , total effective rate of gorup D was significantly higher than the group B and group C, differences were statistically significant (all P <0.05).After treatment, stool frequency , character of stool and abdominal pain symptom scores in group B , group C and group D were sig-nificantly lower than group A;At the same time , the stool frequency , character of stool and abdominal pain symptoms score in group D was significantly lower than group B and group C , The differences were statistical-ly significant ( all P <0.05) .Conclusion: Using live combined bacillus subtilis and enterococcus faecium enteric-coated capsules combined with trimebutine maleate tablets and paroxetine hydrochloride tablets in the treatment of IBS patients can obtain good curative effect , for the minor symptoms can try the bigeminy thera-py.It’ s worthy of attention .