CAJ | 학술논문

目的了解河北省HIV/AIDS的HAART效果.方法以1989-2013年全省报告的4 148例HIV/AIDS进行研究,对发现的HIWAIDS定期随访、检测CD4+T淋巴细胞计数、登记死亡.自2003年开始,对符合HAART条件的HIV/AIDS实施免费治疗.观察截止日期为2013年12月31日.结果 4 148例HIV/AIDS,观察12 451.48人年,全死因死亡968例,死亡密度7.77/100人年,其中接受HAART者死亡密度为2.87/100人年,未接受HAART者死亡密度为16.58/100人年,后者是前者的5.77倍.对1 894例AIDS,自发病之日至观察截止日,观察4 774.48人年,全死因死亡581例,死亡密度121.69/100人年,其中参加HAART者死亡密度4.77/100人年,未参加HAART者死亡密度125.92/100人年.CD4+T淋巴细胞计数＜200 cells/mm3组的死亡密度由不接受HAART治疗的22.9/100人年降至接受HAART治疗的5.3/100人年.通过年度分析发现,随着HIV/AIDS人群HAART覆盖率逐年提高,人群的全死因死亡率逐年下降.HIV人群HAART覆盖率提高,可降低未参加HAART的HIV感染者的死亡率.结论进一步扩大抗病毒治疗覆盖面,可有效减少HIV/AIDS的死亡.
목적 료해하북성HIV/AIDS적HAART효과.방법 이1989-2013년전성보고적4 148례HIV/AIDS진행연구,대발현적HIWAIDS정기수방、검측CD4+T림파세포계수、등기사망.자2003년개시,대부합HAART조건적HIV/AIDS실시면비치료.관찰절지일기위2013년12월31일.결과 4 148례HIV/AIDS,관찰12 451.48인년,전사인사망968례,사망밀도7.77/100인년,기중접수HAART자사망밀도위2.87/100인년,미접수HAART자사망밀도위16.58/100인년,후자시전자적5.77배.대1 894례AIDS,자발병지일지관찰절지일,관찰4 774.48인년,전사인사망581례,사망밀도121.69/100인년,기중삼가HAART자사망밀도4.77/100인년,미삼가HAART자사망밀도125.92/100인년.CD4+T림파세포계수＜200 cells/mm3조적사망밀도유불접수HAART치료적22.9/100인년강지접수HAART치료적5.3/100인년.통과년도분석발현,수착HIV/AIDS인군HAART복개솔축년제고,인군적전사인사망솔축년하강.HIV인군HAART복개솔제고,가강저미삼가HAART적HIV감염자적사망솔.결론 진일보확대항병독치료복개면,가유효감소HIV/AIDS적사망.
Objective To investigate the effect of highly active anti-retroviral therapy (HAART) on reducing HIV/AIDS related death.Methods The analysis was conducted by using the data of 4 148 HIV/AIDS cases reported in Hebei province from 1989 to 2013.Regular follow-up,CD4 detection,registration of death were carried out for them.Free HAART has been provided to people living with HIV/AIDS who met the treatment requirement since 2003.Results Of 4 148 HIV/AIDS cases,12 451.48 person years were observed,968 cases died due to all registered death causes.The death density was 7.77/100 person years.The death density was 2.87/100 person years for the HIV/AIDS cases receiving HAART,and 16.58/100 for the HIV/AIDS cases receiving no HAART.In 1 894 AIDS cases,a total of 4 774.48 person years were observed from onset to death,581 cases died due to all registered death causes,and the death density was 121.69/100 person years.The death density was 4.77/100 person years for the cases receiving HAART,and 125.92/100 person years for the cases receiving no HAART.In the cases with CD less than 200/mm3,the death density was 22.9/ 100 person years for those receiving no HAART and 5.3/100 person years for those receiving HAART.The annual analysis found that the death rate due to all registered death causes declined as the increase of HAART coverage in people living with HIV/AIDS.The expanding of HAART coverage in people infected with HIV can reduce death rate among them.Conclusion Further expanding of HAART can effectively reduce the death among people living with HIV/AIDS.