中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2015年
5期
1016-1018
,共3页
邹新华%鄢丽%祝友鹏%祝鑫红%李恭弛%李炳辉
鄒新華%鄢麗%祝友鵬%祝鑫紅%李恭弛%李炳輝
추신화%언려%축우붕%축흠홍%리공이%리병휘
壳聚糖%麻油%蜂蜡%创面愈合
殼聚糖%痳油%蜂蠟%創麵愈閤
각취당%마유%봉사%창면유합
Chitosan%Sesame oil%Beeswax%Wound healing
目的 测定改性壳聚糖麻油蜂蜡海绵的物理性质评估其保湿性,观察其促进创面愈合的效果并探讨其机制.方法 分别测定纱布(A)、改性壳聚糖麻油蜂蜡无纺布(B)、改性壳聚糖海绵(C)、改性壳聚糖麻油蜂蜡海绵(D)4种敷料的吸水、失水、透气速率,并计算吸水率及水蒸气透过率(WVTR).将12只SD大鼠背部两侧对称部位造成两个全层皮肤缺损创面,随机分组,并分别用A、B、C、D4种敷料每隔2d换药,于第1、7、14、21天计算创面愈合率及CD31的表达.结果 改性壳聚糖麻油蜂蜡海绵的吸水率为自身重量的111％,吸水速率及失水速率稳定持久;水蒸气透过率(WVTR)为1 080.82 g/(m2·d),保湿性良好,透气性欠佳.D组创面愈合率在第14、21天为(80.99±3.06)％、(97.59±1.00)％,与其他各组比较差异有统计学意义(P＜0.05);D组毛细血管密度第7天与B、C两组比较差异无统计学意义(P＞0.05),第14、21天与其他各组比较差异有统计学意义(P＜0.05).结论 改性壳聚糖麻油蜂蜡海绵具有良好的保湿性,能够促进创面愈合及创面组织中CD31的表达,有利于创面新生血管的生长.
目的 測定改性殼聚糖痳油蜂蠟海綿的物理性質評估其保濕性,觀察其促進創麵愈閤的效果併探討其機製.方法 分彆測定紗佈(A)、改性殼聚糖痳油蜂蠟無紡佈(B)、改性殼聚糖海綿(C)、改性殼聚糖痳油蜂蠟海綿(D)4種敷料的吸水、失水、透氣速率,併計算吸水率及水蒸氣透過率(WVTR).將12隻SD大鼠揹部兩側對稱部位造成兩箇全層皮膚缺損創麵,隨機分組,併分彆用A、B、C、D4種敷料每隔2d換藥,于第1、7、14、21天計算創麵愈閤率及CD31的錶達.結果 改性殼聚糖痳油蜂蠟海綿的吸水率為自身重量的111％,吸水速率及失水速率穩定持久;水蒸氣透過率(WVTR)為1 080.82 g/(m2·d),保濕性良好,透氣性欠佳.D組創麵愈閤率在第14、21天為(80.99±3.06)％、(97.59±1.00)％,與其他各組比較差異有統計學意義(P＜0.05);D組毛細血管密度第7天與B、C兩組比較差異無統計學意義(P＞0.05),第14、21天與其他各組比較差異有統計學意義(P＜0.05).結論 改性殼聚糖痳油蜂蠟海綿具有良好的保濕性,能夠促進創麵愈閤及創麵組織中CD31的錶達,有利于創麵新生血管的生長.
목적 측정개성각취당마유봉사해면적물이성질평고기보습성,관찰기촉진창면유합적효과병탐토기궤제.방법 분별측정사포(A)、개성각취당마유봉사무방포(B)、개성각취당해면(C)、개성각취당마유봉사해면(D)4충부료적흡수、실수、투기속솔,병계산흡수솔급수증기투과솔(WVTR).장12지SD대서배부량측대칭부위조성량개전층피부결손창면,수궤분조,병분별용A、B、C、D4충부료매격2d환약,우제1、7、14、21천계산창면유합솔급CD31적표체.결과 개성각취당마유봉사해면적흡수솔위자신중량적111％,흡수속솔급실수속솔은정지구;수증기투과솔(WVTR)위1 080.82 g/(m2·d),보습성량호,투기성흠가.D조창면유합솔재제14、21천위(80.99±3.06)％、(97.59±1.00)％,여기타각조비교차이유통계학의의(P＜0.05);D조모세혈관밀도제7천여B、C량조비교차이무통계학의의(P＞0.05),제14、21천여기타각조비교차이유통계학의의(P＜0.05).결론 개성각취당마유봉사해면구유량호적보습성,능구촉진창면유합급창면조직중CD31적표체,유리우창면신생혈관적생장.
Objective By measuring the physical properties of modified-chitosan spong dressing composited with beewax-sesameoil to assess its moisturizing properties,and observe its effect promoting wound healing and explore its mechanism.Methods Water absorption,dehydration,and permeability rate of gauze (A),modified-chitosan non-woven fabric composited with beewax-sesameoil (B),modified-chitosan sponge (C),and modified-chitosan spong dressing composited with beewax-sesameoil (D) were measured,and water absorption rate and water vapor transmission rate (WVTR) were calculated.Two full-thickness skin wounds were created on the back of the 12 SD rats each bilaterally and symmetrically,and were divided into two groups randomly,the first group on the left provides wound rats in group A (NS gauze group),the right of the wound for group B (modified-chitosan non-woven fabric composited with beewax-sesameoil group),the left side of the wound for the second group of rats in group C (modified-chitosan sponge group),the right of the wound for D group (modified-Chitosan spong dressing composited with beewax-sesameoil group).After dressing process modeling conducted every two days,the wound healing rate and CD31 expression with the first,7th,14th,21th day.Results Modified-Chitosan spong dressing composited with beewax-sesameoil showed a water absorption 111％ of its own weight.Its water absorption rate and loss rate is stable and lasting;Water vapor transmission rate (WVTR)is 1 080.82 g/(m2·d).Its moisture resistance is good,but its breathability is unsatisfactory.The wound healing rate of group D was (80.99 ± 3.06) ％,(97.59 ± 1.00) ％ at 14th,21th day.There was significant difference with other groups.At 14th and 21th days,the wound healing rate of group D were better than other groups.There were no significant differences in capillary density between group D and B,C group at 7th day.At 14th and 21th days,the capillary density of group D were significant differences with other groups.Conclusion Modified-chitosan spong dressing composited with beewax-sesameoil with good moisture resistance,can promote wound healing and wound tissue expression of CD31,is conducive to the growth of new blood vessels wounds.
