中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2015年
5期
1159-1161
,共3页
徐勇超%任莹坤%唐礼恭%刘英俊%陈小兵%王刚成%李克%黄涛
徐勇超%任瑩坤%唐禮恭%劉英俊%陳小兵%王剛成%李剋%黃濤
서용초%임형곤%당례공%류영준%진소병%왕강성%리극%황도
CXCL5%胃癌
CXCL5%胃癌
CXCL5%위암
chemokine (C-X-C motif) ligand 5%Gastric cancer
目的 探讨趋化因子CXCL5在胃癌中的表达及其与临床病理特征及预后的关系,分析其在肿瘤发生发展、侵袭转移中的作用.方法 收集260例胃癌组织标本,其中60例收集血清标本.采用免疫组织化学法检测胃癌组织和正常黏膜中CXCL5蛋白表达,采用酶联免疫吸附试验法检测患者和正常志愿者血清中CXCL5含量,并分析其与临床病理特征及预后的关系.结果 CXCL5蛋白在胃癌组织中的阳性表达率[37.69% (86/260)]高于周围正常组织[6.53% (17/260),P<0.01];癌组织中CXCL5表达与肿瘤大小(P< 0.05)、病理类型(P<0.05)、脉管癌栓(P<0.05)、T分期(P<0.05)、N分期(P<0.05)明显相关;CXCL5表达是胃癌患者的独立预后因素(P<0.05).胃癌患者血清CXCL5的含量(985.46 ng/L)明显高于正常对照(628.49 ng/L,P<0.01),且与肿瘤大小(P<0.05)、脉管癌栓(P<0.05)、T分期(P<0.05)、M分期(P<0.05)明显相关.结论 CXCL5在胃癌中高表达,与胃腺癌的临床分期、病理分级呈正相关,与患者生存率负相关.CXCL5可能在胃癌的发生发展、侵袭转移发挥作用.
目的 探討趨化因子CXCL5在胃癌中的錶達及其與臨床病理特徵及預後的關繫,分析其在腫瘤髮生髮展、侵襲轉移中的作用.方法 收集260例胃癌組織標本,其中60例收集血清標本.採用免疫組織化學法檢測胃癌組織和正常黏膜中CXCL5蛋白錶達,採用酶聯免疫吸附試驗法檢測患者和正常誌願者血清中CXCL5含量,併分析其與臨床病理特徵及預後的關繫.結果 CXCL5蛋白在胃癌組織中的暘性錶達率[37.69% (86/260)]高于週圍正常組織[6.53% (17/260),P<0.01];癌組織中CXCL5錶達與腫瘤大小(P< 0.05)、病理類型(P<0.05)、脈管癌栓(P<0.05)、T分期(P<0.05)、N分期(P<0.05)明顯相關;CXCL5錶達是胃癌患者的獨立預後因素(P<0.05).胃癌患者血清CXCL5的含量(985.46 ng/L)明顯高于正常對照(628.49 ng/L,P<0.01),且與腫瘤大小(P<0.05)、脈管癌栓(P<0.05)、T分期(P<0.05)、M分期(P<0.05)明顯相關.結論 CXCL5在胃癌中高錶達,與胃腺癌的臨床分期、病理分級呈正相關,與患者生存率負相關.CXCL5可能在胃癌的髮生髮展、侵襲轉移髮揮作用.
목적 탐토추화인자CXCL5재위암중적표체급기여림상병리특정급예후적관계,분석기재종류발생발전、침습전이중적작용.방법 수집260례위암조직표본,기중60례수집혈청표본.채용면역조직화학법검측위암조직화정상점막중CXCL5단백표체,채용매련면역흡부시험법검측환자화정상지원자혈청중CXCL5함량,병분석기여림상병리특정급예후적관계.결과 CXCL5단백재위암조직중적양성표체솔[37.69% (86/260)]고우주위정상조직[6.53% (17/260),P<0.01];암조직중CXCL5표체여종류대소(P< 0.05)、병리류형(P<0.05)、맥관암전(P<0.05)、T분기(P<0.05)、N분기(P<0.05)명현상관;CXCL5표체시위암환자적독립예후인소(P<0.05).위암환자혈청CXCL5적함량(985.46 ng/L)명현고우정상대조(628.49 ng/L,P<0.01),차여종류대소(P<0.05)、맥관암전(P<0.05)、T분기(P<0.05)、M분기(P<0.05)명현상관.결론 CXCL5재위암중고표체,여위선암적림상분기、병리분급정정상관,여환자생존솔부상관.CXCL5가능재위암적발생발전、침습전이발휘작용.
Objective To explore the expression ofchemokine (C-X-C motif) ligand (CXCL)5 in patients with gastric cancer and analysize the roles of CXCL5 in the development,invasion and metastasis of gastric cancer.Methods The tissue specimens of 260 patients surgically treated in the Department of General Surgery,Affiliated Tumor Hospital of Zhengzhou University were collected,and 60 serum samples were collected.The expression of CXCL5 protein in tumor tissues and case-paired normal tissue samples was detected by immunohistochemistry (IHC).The concentration of serum CXCL5 in 60 cases of gastric cancer and 25 healthy volunteers was measured by enzyme linked immunosorbent assay (ELISA).Results The IHC revealed that the positive expression rate of CXCL5 was significantly higher in tumor tissues [37.69% (86/260)] than in corresponding normal tissues [6.53% (17/260),P < 0.01].The expression of CXCL5 was correlated with tumor size (P < 0.05),pathological types (P < 0.05),intravascular cancer emboli (P < 0.05),T staging (P < 0.05) and N staging (P < 0.05).The expression of CXCL5 was the independent risk factor of poor prognosis in patients with gastric cancer (P < 0.05).The concentration of serum CXCL5 in gastric cancer patients (985.46 ng/L) was higher than in healthy controls (628.49 ng/L,P < 0.01).High level of CXCL5 was correlated with tumor size (P < 0.05),intravascular cancer emboli (P < 0.05),T staging (P < 0.05) and M staging (P < 0.05).Conclusion The over-expression and increased concentration of CXCL5 were associated with clinical staging,pathological grade and survival time.CXCL5 may play an important role in the development,invasion and metastasis of gastric cancer.