北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2015年
5期
32-32,33
,共2页
小剂量米非司酮%孕三烯酮%子宫内膜异位症术后
小劑量米非司酮%孕三烯酮%子宮內膜異位癥術後
소제량미비사동%잉삼희동%자궁내막이위증술후
Low dose of mifepristone%Pregnan three ketene%Endometriosis after conservative surgery
目的：观察比较小剂量米非司酮与孕三烯酮治疗子宫内膜异位症术后的临床效果。方法：回顾性分析2005年1月～2014年6月在我院就诊的235例子宫内膜异位症术后病例，随机分为小剂量米非司酮和孕三烯酮治疗两组，通过术后的随访研究，比较术后应用小剂量米非司酮和孕三烯酮的复发率和不良反应发生率。结果：小剂量米非司酮组、孕三烯酮组对子宫内膜异位症术后的缓解和改善症状都有效，有效率均>80%，效果对比P<0.01，差异有统计学意义，小剂量米非司酮组的疗效优于孕三烯酮组。不良反应方面两组均有阴道少量出血，小剂量米非司酮组少于孕三烯酮组（P<0.01），差异有统计学意义。皮肤黏膜变化、胃肠道反应、肝功能异常经统计学处理P>0.05，两组差异均无统计学意义。结论：小剂量米非司酮和孕三烯酮治疗子宫内膜异位症术后,能显著降低该病复发率，米非司酮可使异位子宫内膜萎缩、疼痛缓解，对炎性因子有一定抑制作用。比较两组治疗结果，小剂量米非司酮组的疗效优于孕三烯酮组[3]，小剂量米非司酮组的不良反应少于孕三烯酮组[4]，更易被患者接受，也是最经济可行的。因此，小剂量米非司酮可作为治疗子宫内膜异位症的临床一线药物使用。
目的：觀察比較小劑量米非司酮與孕三烯酮治療子宮內膜異位癥術後的臨床效果。方法：迴顧性分析2005年1月～2014年6月在我院就診的235例子宮內膜異位癥術後病例，隨機分為小劑量米非司酮和孕三烯酮治療兩組，通過術後的隨訪研究，比較術後應用小劑量米非司酮和孕三烯酮的複髮率和不良反應髮生率。結果：小劑量米非司酮組、孕三烯酮組對子宮內膜異位癥術後的緩解和改善癥狀都有效，有效率均>80%，效果對比P<0.01，差異有統計學意義，小劑量米非司酮組的療效優于孕三烯酮組。不良反應方麵兩組均有陰道少量齣血，小劑量米非司酮組少于孕三烯酮組（P<0.01），差異有統計學意義。皮膚黏膜變化、胃腸道反應、肝功能異常經統計學處理P>0.05，兩組差異均無統計學意義。結論：小劑量米非司酮和孕三烯酮治療子宮內膜異位癥術後,能顯著降低該病複髮率，米非司酮可使異位子宮內膜萎縮、疼痛緩解，對炎性因子有一定抑製作用。比較兩組治療結果，小劑量米非司酮組的療效優于孕三烯酮組[3]，小劑量米非司酮組的不良反應少于孕三烯酮組[4]，更易被患者接受，也是最經濟可行的。因此，小劑量米非司酮可作為治療子宮內膜異位癥的臨床一線藥物使用。
목적：관찰비교소제량미비사동여잉삼희동치료자궁내막이위증술후적림상효과。방법：회고성분석2005년1월～2014년6월재아원취진적235례자궁내막이위증술후병례，수궤분위소제량미비사동화잉삼희동치료량조，통과술후적수방연구，비교술후응용소제량미비사동화잉삼희동적복발솔화불량반응발생솔。결과：소제량미비사동조、잉삼희동조대자궁내막이위증술후적완해화개선증상도유효，유효솔균>80%，효과대비P<0.01，차이유통계학의의，소제량미비사동조적료효우우잉삼희동조。불량반응방면량조균유음도소량출혈，소제량미비사동조소우잉삼희동조（P<0.01），차이유통계학의의。피부점막변화、위장도반응、간공능이상경통계학처리P>0.05，량조차이균무통계학의의。결론：소제량미비사동화잉삼희동치료자궁내막이위증술후,능현저강저해병복발솔，미비사동가사이위자궁내막위축、동통완해，대염성인자유일정억제작용。비교량조치료결과，소제량미비사동조적료효우우잉삼희동조[3]，소제량미비사동조적불량반응소우잉삼희동조[4]，경역피환자접수，야시최경제가행적。인차，소제량미비사동가작위치료자궁내막이위증적림상일선약물사용。
Objective:Comparison of the clinncal effect of small dose of mifeprisone and pregnant three ketene treatment of endometriosis after operation.Methods: A retrospective analysis of 2005 Jauaary to 2014 June in ourhospital 235 cases of endomertosis postoperotive patients,divided into low dose mifepristone and pregnant three ketene treatment group two,through the analysis of follow up study of 235 case of patienta with pelcic endometriosis after I institute.Theincidence of low dose mifepritone and pregnant three ketene campared postopercitive recurrence rate and side reaction. Results:A low dose mifepritone group, pregnant three ketene two groups onpostoperative endometriosis patients ease and improve the symptomswere effective, the effective rate was >80%. the effect of contrast on the P<0.01, there was significant difference between two groups, small dose of mifepristone group curative effect surpasses the pregnant threeketene group. The side reaction, a small amount of vaginal bleeding:(P<0.01)with small dose of mifepristone group less than pregnant threeketene group two groups, there was significant difference between. The change of skin mucosa, gastrointestinal reaction, liver function abnormalities were P<0.05, the two groups showed no significant differences. Conclusion: Low dose mifepristone and pregnant three ketene treatment of pelvicendometriosis postoperative patients, cansignificaritly reduce the incidence ofendometriosis.Mifepristone can cause the atrophy of ectopic endometrium,pain felief, and hasinhibitory effects oninflammatory factcrs.The comparisonresult low dose of mifepristone group cuiative effect surpasses the prengnant three ketene group [3],the same side effects of low dose mifepristone is lessthan pregnant threee rctene group [4],moreeasily accepted by the patients,from the econnmics point of view,which is the most economical and feasible.So the low dose mifepristone can be use as the fist-line drugs for the treatment of endometriosis disease.
