CAJ | 학술논문

核因子E2相关因子2是重要的氧化还原调节剂。基础条件下，核因子E2相关因子2位于细胞浆，与抑制因子Keap1结合而降解；在应激因素作用下，核因子E2相关因子2激活并与Keap1解离，转位于细胞核内，与多种抗氧化应激基因和Ⅱ相解毒酶的抗氧化反应元件结合，促进血红素氧化酶1等抗氧化应激蛋白和多种解毒酶的表达增加，进而发挥抗氧化应激调节作用。研究显示，核因子E2相关因子2及其靶基因激活在保护内皮功能、血管生成、心肌再生和支架内再狭窄等方面发挥重要作用。现综述核因子E2相关因子2与心血管疾病相关研究的新进展。
핵인자E2상관인자2시중요적양화환원조절제。기출조건하，핵인자E2상관인자2위우세포장，여억제인자Keap1결합이강해；재응격인소작용하，핵인자E2상관인자2격활병여Keap1해리，전위우세포핵내，여다충항양화응격기인화Ⅱ상해독매적항양화반응원건결합，촉진혈홍소양화매1등항양화응격단백화다충해독매적표체증가，진이발휘항양화응격조절작용。연구현시，핵인자E2상관인자2급기파기인격활재보호내피공능、혈관생성、심기재생화지가내재협착등방면발휘중요작용。현종술핵인자E2상관인자2여심혈관질병상관연구적신진전。
Nuclear factor E2-related factor 2 ( Nrf2) is an important redox regulator.Under basal conditions, Nrf2 is localized in the cytoplasm where it binds to the Kelch like ECH associating protein (Keap1) and is degraded by the proteasome pathway.Once the cells are exposed to various oxidative or electrophilic inducers, Nrf2 is dissociated from Keap1 and translocates to the nucleus where, by binding to the anti-oxidant response element in the promoters of many anti-oxidant genes such as heme oxygenase-1, and it induces their expression.It has been reported that Nrf2 and its target proteins play critical roles in the protection of endothelial function, angiogenesis, regeneration of cardiac cells and in-stent restenosis and so on.In this paper, the progress in identifying the relationship between Nrf2 and cardiovascular disease are reviewed.