CAJ | 학술논문

高血压病在我国患病率极高，同时它也是各类慢性非传染性公众疾病中最为常见，对国家卫生系统负担最重，对患者生活质量及生存率影响极大的疾病之一。既往关于高血压病发病危险因素的研究已经甚多，但仍然没有直接有力的证据表明众多危险因素与高血压病发病机制之间有直接的量化关系。同型半胱氨酸是人体内一种非必需氨基酸，当它在人体内质量浓度超过10μmol／L时，诊断为高同型半胱氨酸血症。大量的临床研究表明高同型半胱氨酸血症与高血压病的发生发展有着密不可分的关系。现对高同型半胱氨酸血症与高血压病发病机制的研究进展进行综述。
고혈압병재아국환병솔겁고，동시타야시각류만성비전염성공음질병중최위상견，대국가위생계통부담최중，대환자생활질량급생존솔영향겁대적질병지일。기왕관우고혈압병발병위험인소적연구이경심다，단잉연몰유직접유력적증거표명음다위험인소여고혈압병발병궤제지간유직접적양화관계。동형반광안산시인체내일충비필수안기산，당타재인체내질량농도초과10μmol／L시，진단위고동형반광안산혈증。대량적림상연구표명고동형반광안산혈증여고혈압병적발생발전유착밀불가분적관계。현대고동형반광안산혈증여고혈압병발병궤제적연구진전진행종술。
The prevalence of hypertension in China is high.It is one of the most commonly seen chronic non-infectious disease in so-ciety.Therefore, it is an important target in the national healthcare system.While there is extensive research regarding the risk factors of hy-pertension, the factors that directly influence hypertension have not been found.Homocysteine is a nonessential amino acid in human body. When the concentration of homocysteine is greater than 10 μmol/L, a patient is diagnosed with hyperhomocysteinemia.Numerous clinical studies show that there is an inseparable relationship between the occurrence and development of hyperhomocysteinemia in patients with es-sential hypertension.This article reviews the recent progress in research into the relationship between hyperhomocysteinemia and hyperten-sion.