CAJ | 학술논문

心房肌细胞凋亡、心房结构和功能出现不可逆改变导致心房颤动。血管紧张素Ⅱ（ AngⅡ）是肾素－血管紧张素系统的关键效应产物，血管紧张素转换酶是生成AngⅡ的关键酶，AngⅡ可诱导心肌细胞凋亡。高甲状腺素致心房颤动有多种机制，其中可能的机制之一是高甲状腺素增强血管紧张素转换酶的活性，激活肾素－血管紧张素系统，AngⅡ高表达，后者进一步促进心房肌细胞凋亡导致心房颤动。
심방기세포조망、심방결구화공능출현불가역개변도치심방전동。혈관긴장소Ⅱ（ AngⅡ）시신소－혈관긴장소계통적관건효응산물，혈관긴장소전환매시생성AngⅡ적관건매，AngⅡ가유도심기세포조망。고갑상선소치심방전동유다충궤제，기중가능적궤제지일시고갑상선소증강혈관긴장소전환매적활성，격활신소－혈관긴장소계통，AngⅡ고표체，후자진일보촉진심방기세포조망도치심방전동。
Atrial structure and function incur irreversible damage during cardiomyocyte apoptosis.This leads to atrial fibrillation.An-giotensinⅡis a critical product of the renin-angiotensin system.The presence of the angiotensin-converting enzyme is the key to the produc-tion of angiotensinⅡ, and angiotensin Ⅱmay promote the apoptosis of cardiomyocytes.In turn, high thyroxine levels may lead to an in-crease in angiotensin-converting enzyme activity, which increases the production of angiotensinⅡ, thereby leading to atrial fibrillation.