CAJ | 학술논문

目的探讨苯唑啉和丙吡胺在治疗心血管术后阵发性心房纤颤的差异.方法对118例心血管术后阵发性心房纤颤持续30 min的患者随机分别静脉注射苯唑啉(70 mg,n =60)和丙吡胺(50 mg,n =58)终止心房纤颤;多变量Logistic回归调整协变量后确定增加苯唑啉和丙吡胺终止心血管术后心房纤颤治疗效果的预测因素.结果静脉注射苯唑啉成功率为46.67％ (28/60),显著优于静脉注射丙吡胺的成功率[24.13％ (14/58),P＜0.05];术前口服β受体阻滞剂[比值比(OR)=8.224,P＜0.05]和小左房直径(OR=0.879,P＜0.05)对于苯唑啉终止心房纤颤是有意义预测因素.结论静脉注射苯唑啉终止心血管术后阵发性心房纤颤的效果要好于静脉注射丙吡胺,对与术前口服β受体阻滞剂和左心房较小的患者治疗效果更好.
목적 탐토분서람화병필알재치료심혈관술후진발성심방섬전적차이.방법 대118례심혈관술후진발성심방섬전지속30 min적환자수궤분별정맥주사분서람(70 mg,n =60)화병필알(50 mg,n =58)종지심방섬전;다변량Logistic회귀조정협변량후학정증가분서람화병필알종지심혈관술후심방섬전치료효과적예측인소.결과 정맥주사분서람성공솔위46.67％ (28/60),현저우우정맥주사병필알적성공솔[24.13％ (14/58),P＜0.05];술전구복β수체조체제[비치비(OR)=8.224,P＜0.05]화소좌방직경(OR=0.879,P＜0.05)대우분서람종지심방섬전시유의의예측인소.결론 정맥주사분서람종지심혈관술후진발성심방섬전적효과요호우정맥주사병필알,대여술전구복β수체조체제화좌심방교소적환자치료효과경호.
Objective To investigate the divergence of cibenzoline and disopyramide in the treatment of paroxysmal atrial fibrillation after cardiovascular surgery.Methods 118 patients who had postoperative paroxysmal AF lasting ≥ 30 min were randomly assigned to receive either intravenous cibenzoline (70 mg,n =60) or disopyramide (50 mg,n =58) for terminating postoperative paroxysmal AF.Multivariate logistic regression was used to adjust several covariates and to generate adjusted odds ratios (OR) to identify clinical factors to increase the termination efficacy of intravenous cibenzoline and disopyramide.Results The success rate of intravenous cibenzoline therapy 46.67％ (28/60) was significantly higher than that of intravenous disopyramide therapy [24.13％ (14/58),P ＜ 0.05].The significant variables for the termination of paroxysmal AF after intravenous cibenzoline therapy were pretreatment with oral β-adrenergic blockers (OR =8.224,P ＜ 0.05) and smaller left atrial dimensions (OR =0.879,P ＜ 0.05).Conclusion The efficacy of intravenous cibenzoline for the termination of postoperative paroxysmal AF was more satisfactory than that of disopyramide,especially in patients with pre-administration of oral β-adrenergic blockers and those with smaller left atrium.