安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2015年
5期
929-931
,共3页
何子彬%杨清强%周骥%何元清
何子彬%楊清彊%週驥%何元清
하자빈%양청강%주기%하원청
胃食管反流%临床特点%功能性肠道疾病
胃食管反流%臨床特點%功能性腸道疾病
위식관반류%림상특점%공능성장도질병
gastroesophageal reflux disease%clinical features%functional bowel diseases
探讨胃食管反流病（GERD）合并功能性肠病的发生情况及其相关因素。方法2010年1月—2014年6月该院消化科门诊收治具有典型反流症状的患者254例，采用反流性疾病问卷（RDQ）对其典型反流症状评分，RDQ 评分≥12分诊断GERD，并结合胃镜检查结果和对质子泵抑制剂治疗的反应将 GERD 患者分为反流性食管炎（RE ）和非糜烂性反流病（NERD）。按照罗马Ⅲ诊断标准筛选患者是否患有功能性肠道疾病（FBD）。结果诊断为GERD的患者162例，肠易激综合征（IBS）56例，功能性腹泻（FD）32例，功能型便秘（FC）22例，功能性腹胀（FB）5例，功能性肠病患者共115例。GERD与IBS、FD、FC、FB的重叠率均高于对照组；与对照组相比，其中与IBS重叠率有显著统计学差异（P ＜0．05），FD、FC、FB的重叠率无显著统计学差异（P＞0．05）。与RE相比，NERD合并FBD的比例较高，但差异无统计学意义（P＞0．05）。GERD患者的RQD评分与发生功能性肠道疾病的重叠有相关性（P＜0．05）。结论 GERD与IBS、FD、FC、FB均有一定的重叠，其中IBS及FD的重叠率最高。GERD患者的RQD评分越高，与功能性肠道疾病发生重叠的几率越大。
探討胃食管反流病（GERD）閤併功能性腸病的髮生情況及其相關因素。方法2010年1月—2014年6月該院消化科門診收治具有典型反流癥狀的患者254例，採用反流性疾病問捲（RDQ）對其典型反流癥狀評分，RDQ 評分≥12分診斷GERD，併結閤胃鏡檢查結果和對質子泵抑製劑治療的反應將 GERD 患者分為反流性食管炎（RE ）和非糜爛性反流病（NERD）。按照囉馬Ⅲ診斷標準篩選患者是否患有功能性腸道疾病（FBD）。結果診斷為GERD的患者162例，腸易激綜閤徵（IBS）56例，功能性腹瀉（FD）32例，功能型便祕（FC）22例，功能性腹脹（FB）5例，功能性腸病患者共115例。GERD與IBS、FD、FC、FB的重疊率均高于對照組；與對照組相比，其中與IBS重疊率有顯著統計學差異（P ＜0．05），FD、FC、FB的重疊率無顯著統計學差異（P＞0．05）。與RE相比，NERD閤併FBD的比例較高，但差異無統計學意義（P＞0．05）。GERD患者的RQD評分與髮生功能性腸道疾病的重疊有相關性（P＜0．05）。結論 GERD與IBS、FD、FC、FB均有一定的重疊，其中IBS及FD的重疊率最高。GERD患者的RQD評分越高，與功能性腸道疾病髮生重疊的幾率越大。
탐토위식관반류병（GERD）합병공능성장병적발생정황급기상관인소。방법2010년1월—2014년6월해원소화과문진수치구유전형반류증상적환자254례，채용반류성질병문권（RDQ）대기전형반류증상평분，RDQ 평분≥12분진단GERD，병결합위경검사결과화대질자빙억제제치료적반응장 GERD 환자분위반류성식관염（RE ）화비미란성반류병（NERD）。안조라마Ⅲ진단표준사선환자시부환유공능성장도질병（FBD）。결과진단위GERD적환자162례，장역격종합정（IBS）56례，공능성복사（FD）32례，공능형편비（FC）22례，공능성복창（FB）5례，공능성장병환자공115례。GERD여IBS、FD、FC、FB적중첩솔균고우대조조；여대조조상비，기중여IBS중첩솔유현저통계학차이（P ＜0．05），FD、FC、FB적중첩솔무현저통계학차이（P＞0．05）。여RE상비，NERD합병FBD적비례교고，단차이무통계학의의（P＞0．05）。GERD환자적RQD평분여발생공능성장도질병적중첩유상관성（P＜0．05）。결론 GERD여IBS、FD、FC、FB균유일정적중첩，기중IBS급FD적중첩솔최고。GERD환자적RQD평분월고，여공능성장도질병발생중첩적궤솔월대。
Objective To investigate incidence of GERD (gastrooesophageal reflux disease,GERD)combined with functional bowel diseases and analyze the factors related to such overlap.Methods A total of 254 outpatients treated at our hospital from January 2010 to June 2014 due to typical reflux symptoms were included in the study.GERD was diagnosed when the score(Sc)of reflux diagnostic questionnaire (RDQ)was greater than or equal to 12.Reflux esophagitis (RE)and non-erosive reflux disease (NERD)were differ-entiated according to RQD scores,endoscopic diagnosis and response to proton pump inhibitor therapy.Functional bowel diseases (FBD)was diagnosed based on RomeⅢ criteria.Results 162 patients were diagnosed with GERD.A total of 1 15 cases of FBD were diagnosed,including 56 irritable bowel disease,32 functional diarrhea,22 functional constipation and 5 functional bloating.The preva-lences of IBS,FD,FC and FB in GERD patients were higher than those in control patients.The incidence of IBS in GERD patients was significantly higher than that in control patients (P <0.05),though no significant difference was observed in the prevalences of FD, FC and FB between the two groups(P >0.05).Compared with RE,NERD had higher rate of overlapping with FBD,but the difference was not statistically significant (P >0.05).GERD symptom score was significantly related with the overlap of GERD and functional bowel disease (P <0.05).Conclusions IBS,FD,FC and FB in GERD patients are more prevalent than those in the general popula-tion,and the prevalence of IBS in GERD patients is significantly higher than that in the general population.GERD symptom score has significant relation with the overlap of GERD and functional bowel diseases.
