CAJ | 학술논문

目的：探讨血浆（1，3）-β-D葡聚糖检测对侵袭性真菌病的早期诊断意义。方法通过回顾性分析105例怀疑侵袭性真菌病的住院患者的血浆（1，3）-β-D葡聚糖含量和真菌培养结果，分别计算两种方法的阳性率及灵敏度、特异度、阳性和阴性预测值。结果侵袭性真菌病患者的血浆（1，3）-β-D葡聚糖检测阳性率和真菌培养阳性率分别是为80．00％和66．67％，两组差异有统计学意义（P＜0．05）；血浆（1，3）-β-D葡聚糖检测阳性者血浆（1，3）-β-D葡聚糖含量为（62．0±21．34）ng·L－1，阴性者为（5．1±2．03）ng·L－1，两组差异有统计学意义（P＜0．05）；葡聚糖检测灵敏度和特异度为80．0％和91．7％，葡聚糖检测的阳性预测值和阴性预测值分别为87．8％和85．9％，均较真菌培养高。结论血浆（1，3）-β-D葡聚糖检测方法快速、阳性率高、灵敏度和特异度高，可用于侵袭性真菌病的早期诊断。
목적：탐토혈장（1，3）-β-D포취당검측대침습성진균병적조기진단의의。방법통과회고성분석105례부의침습성진균병적주원환자적혈장（1，3）-β-D포취당함량화진균배양결과，분별계산량충방법적양성솔급령민도、특이도、양성화음성예측치。결과침습성진균병환자적혈장（1，3）-β-D포취당검측양성솔화진균배양양성솔분별시위80．00％화66．67％，량조차이유통계학의의（P＜0．05）；혈장（1，3）-β-D포취당검측양성자혈장（1，3）-β-D포취당함량위（62．0±21．34）ng·L－1，음성자위（5．1±2．03）ng·L－1，량조차이유통계학의의（P＜0．05）；포취당검측령민도화특이도위80．0％화91．7％，포취당검측적양성예측치화음성예측치분별위87．8％화85．9％，균교진균배양고。결론혈장（1，3）-β-D포취당검측방법쾌속、양성솔고、령민도화특이도고，가용우침습성진균병적조기진단。
Objective We study the early diagnostic significance of plasma (1,3)-β-D glucan in patients with invasive fungal disease. Methods We retrospectively analyzed the plasma levels of (1 ,3 )-β-D glucan and the results of fungal culture in 45 inpatients with invasive fungal disease and 60 inpatients with non-invasive fungal disease,calculating the positive rate,sensitivity,specificity,positive and negative predictive values of two methods,respectively.Results The positive rates of plasma (1 ,3 )-β-D glucan and fungal cul-ture in the inpatients with invasive fungal disease were 80.00% and 66.67%,respectively,and the difference of two methods is significant (P<0.05).The plasma concentration of (1,3)-β-D glucan in positive samples was (62.0 ±21.34)ng·L -1 and in negative samples (5.1 ±2.03)ng·L -1,and the difference of two groups is significant (P<0.05).The sensitivity and spe-cificity of plasma (1,3)-β-D glucan were 80.0% and 91.7%,respectively,and its positive and negative predictive values were 87 .8% and 85 .9%,respectively,and all of them were higher than the values of fungal culture.Conclusions Because the detec-ting method of plasma (1,3)-β-D glucan is with rapidity,high positive rate,high sensitivity and specificity,it can be used for the early diagnosis of invasive fungal disease.