安徽医药
安徽醫藥
안휘의약
ANHUI MEDICAL AND PHARMACEUTICAL JOURNAL
2015年
5期
891-894
,共4页
胡锵%于东风%刘弋%常家聪
鬍鏘%于東風%劉弋%常傢聰
호장%우동풍%류익%상가총
晚期胃癌%核苷酸切除修复交叉互补组1%3型β微管蛋白%个体化化疗
晚期胃癌%覈苷痠切除脩複交扠互補組1%3型β微管蛋白%箇體化化療
만기위암%핵감산절제수복교차호보조1%3형β미관단백%개체화화료
advanced gasric carcinoma%excision repair-cross complementing-1%β-tubulin-3%individualized treatment
目的:通过检测核苷酸切除修复交叉互补组1(excision repair cross complementation group 1,ERCC1)和3型β微管蛋白(β-tubulin-3,TUBB3)在晚期胃癌患者肿瘤组织中的表达,并探讨两者相关性及其临床意义。方法采用免疫组化法检测手术切除的66例晚期胃癌组织及40例癌旁组织中的ERCC1及TUBB3蛋白的表达情况,并结合临床病理资料综合分析。结果ERCC1和TUBB3在晚期胃癌组织中的高表达率分别为59.1%和13.6%,在癌旁正常组织中的高表达率分别为30%和72.5%,两种蛋白高表达率在晚期胃癌组织和正常胃组织间差异均有统计学意义(P<0.05)。ERCC1、TUBB3蛋白表达与性别、年龄、肿瘤大小、浸润深度、淋巴结转移、肿瘤原发部位均无关(P>0.05),但与肿瘤的分化程度相关(P<0.05),ERCC1与TUBB3的表达成负相关。结论在晚期胃癌患者肿瘤组织中ERCC1成高表达、TUBB3呈低表达,两者在癌组织中表达具有密切关系。
目的:通過檢測覈苷痠切除脩複交扠互補組1(excision repair cross complementation group 1,ERCC1)和3型β微管蛋白(β-tubulin-3,TUBB3)在晚期胃癌患者腫瘤組織中的錶達,併探討兩者相關性及其臨床意義。方法採用免疫組化法檢測手術切除的66例晚期胃癌組織及40例癌徬組織中的ERCC1及TUBB3蛋白的錶達情況,併結閤臨床病理資料綜閤分析。結果ERCC1和TUBB3在晚期胃癌組織中的高錶達率分彆為59.1%和13.6%,在癌徬正常組織中的高錶達率分彆為30%和72.5%,兩種蛋白高錶達率在晚期胃癌組織和正常胃組織間差異均有統計學意義(P<0.05)。ERCC1、TUBB3蛋白錶達與性彆、年齡、腫瘤大小、浸潤深度、淋巴結轉移、腫瘤原髮部位均無關(P>0.05),但與腫瘤的分化程度相關(P<0.05),ERCC1與TUBB3的錶達成負相關。結論在晚期胃癌患者腫瘤組織中ERCC1成高錶達、TUBB3呈低錶達,兩者在癌組織中錶達具有密切關繫。
목적:통과검측핵감산절제수복교차호보조1(excision repair cross complementation group 1,ERCC1)화3형β미관단백(β-tubulin-3,TUBB3)재만기위암환자종류조직중적표체,병탐토량자상관성급기림상의의。방법채용면역조화법검측수술절제적66례만기위암조직급40례암방조직중적ERCC1급TUBB3단백적표체정황,병결합림상병리자료종합분석。결과ERCC1화TUBB3재만기위암조직중적고표체솔분별위59.1%화13.6%,재암방정상조직중적고표체솔분별위30%화72.5%,량충단백고표체솔재만기위암조직화정상위조직간차이균유통계학의의(P<0.05)。ERCC1、TUBB3단백표체여성별、년령、종류대소、침윤심도、림파결전이、종류원발부위균무관(P>0.05),단여종류적분화정도상관(P<0.05),ERCC1여TUBB3적표체성부상관。결론재만기위암환자종류조직중ERCC1성고표체、TUBB3정저표체,량자재암조직중표체구유밀절관계。
Objectve Through investigation on the excision repair cross complementation group-1(ERCC1)and β-tubulin-3(TUBB3) in advanced gastric carcinoma to explore their roles and clinical significance in the development of advanced gastric carcinoma.Meth-ods The expression of ERCC1 and TUBB3 in 66 resected patients with advanced gastric carcinoma and corresponding 40 normal tis-sues were detected by the method of immunohistochemistry.Results The high expression rates of ERCC1 and TUBB3 were 59.1%and 13.6% in advanced gastric carcinoma,respectively,and both were higher than those in normal tissues in which the high expression rates were 30%and 72.5%,respectively.The expression of both ERCC1 and TUBB3 showed a significant difference from those in nor-mal gastric tissues(P<0.05).No difference of ERCC1 or TUBB3 protein was found among patients with different genders,ages,tumor size,invasion depth,lymph node metastasis and tumor site (P>0.05),but all related to degrees of differentiation,and there is a nega-tive correlation between ERCC1 and TUBB3.Conclusions In advanced gastric carcinoma,ERCC1 shows high expression rates and TUBB3 shows low expression rates.There is also a negative correlation between ERCC1 and TUBB3 protein expression.