CAJ | 학술논문

目的：探讨老年高血压患者脉压（ PP）／脉压指数（ PPI）与胰岛素抵抗及认知功能的关系。方法选择256例老年高血压病患者进行本研究。①对所有受试者进行MMSE评分，根据评分结果将其分为认知功能正常组和认知功能障碍组，比较两组受试者PP，PPI及血生化指标的差别。②根据PPI不同将受试者分为A， B，C，D 4个不同的组，并根据受试者空腹血糖（FPG）、空腹胰岛素（FINS）计算出胰岛素抵抗指数（IRI），比较不同组之间IRI的差别。结果①认知功能障碍组和认知功能正常组甘油三酯（ TG）、总胆固醇（ TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、肌酐（Cr）差别无统计学意义（P＞0．05）。②认知功能障碍组PP，PPI明显高于认知功能正常组，差异具有统计学意义（P＜0．05）。③B组IRI高于A组，但差异不具有统计学意义（P＞0．05）；C组及D组IRI均高于A组及B组，差异均有显著性（ P＜0．05）；D组IRI高于C组，差异具有统计学意义（ P＜0．05）。结论①老年高血压患者认知功能与PP，PPI有关。②老年高血压患者PPI与胰岛素抵抗密切相关。
목적：탐토노년고혈압환자맥압（ PP）／맥압지수（ PPI）여이도소저항급인지공능적관계。방법선택256례노년고혈압병환자진행본연구。①대소유수시자진행MMSE평분，근거평분결과장기분위인지공능정상조화인지공능장애조，비교량조수시자PP，PPI급혈생화지표적차별。②근거PPI불동장수시자분위A， B，C，D 4개불동적조，병근거수시자공복혈당（FPG）、공복이도소（FINS）계산출이도소저항지수（IRI），비교불동조지간IRI적차별。결과①인지공능장애조화인지공능정상조감유삼지（ TG）、총담고순（ TC）、고밀도지단백（HDL）、저밀도지단백（LDL）、기항（Cr）차별무통계학의의（P＞0．05）。②인지공능장애조PP，PPI명현고우인지공능정상조，차이구유통계학의의（P＜0．05）。③B조IRI고우A조，단차이불구유통계학의의（P＞0．05）；C조급D조IRI균고우A조급B조，차이균유현저성（ P＜0．05）；D조IRI고우C조，차이구유통계학의의（ P＜0．05）。결론①노년고혈압환자인지공능여PP，PPI유관。②노년고혈압환자PPI여이도소저항밀절상관。
Objective To investigate the relationship between congnitive function,insulin resistance and pulse preesure(PP)/pulse pressure index( PPI) in the elderly patients with hypertension.Methods Two hundred and fifty-five elderly patients with hypertension were selected.①According to the score of MMSE,the individuals were divided into group 1(with normal cognition) and group 2(with im-paired cognition) .PP,PPI and blood biochemical indicators were observed and compared in the two groups.②The individuals were divided into 4 groups:group A,B,C and D.Insulin resistance index was calculated through fasting plasma glucose and fasting insulin.Then it com-pared the insulin resistance index in different groups.Results ①There were no significant differences between group 1 and group 2 in TC, TG,HDL,LDL and Cr.②PP and PPI were significantly higher in group 2 than those in group 1(P<0.05).③The IRI in group B had no sta-tistical difference with group A.The IRI in group C and group D was significantly higher than in group A and group B(P<0.05).The IRI in group D was significantly higher than that in group C(P<0.05).Conclusion ①Cognitive function impairment in elderly patients with hy-pertension is closely associated with high PP and PPI.②PPI in elderly patients with hypertension is closely associated with insulin resistance.