北方药学
北方藥學
북방약학
JOURNAL OF NORTH PHARMACY
2015年
5期
139-140,141
,共3页
非对称二甲基精氨酸%盐敏感性高血压%一氧化氮
非對稱二甲基精氨痠%鹽敏感性高血壓%一氧化氮
비대칭이갑기정안산%염민감성고혈압%일양화담
Asymmetric dimethylarginine%Salt-sensitive hypertension%Nitric oxide
目的：探讨盐敏感性高血压患者血清非对称二甲基精氨酸（asymmetric dimethylarginine，ADMA）的测定及其意义。方法：选取100例盐敏感性高血压患者为观察组，选取100例健康体检者为对照组。比较两组血清ADMA水平、血清一氧化氮（nitric oxide， NO）水平；观察不同分级的盐敏感性高血压患者血清ADMA水平差异；采用Pearson相关分析分析血清ADMA水平与血清三酰甘油（triglyceride， TG）、血清总胆固醇（total cholesterol， TC）、血清低密度脂蛋白胆固醇（low density lipoprotein cholesterol ， LDL-C）、血清高密度脂蛋白胆固醇（high density lipoprotein cholesterol， HDL-C）、收缩压（systolic blood pressure，SBP）、舒张压（diastolic blood pressure，DBP）的相关性。结果：观察组血清ADMA和NO水平分别为（3.8±0.8）μmol/L、（33.1±8.9）μmol/L；对照组血清ADMA和NO水平分别为（2.3±0.7）μmol/L、（54.4±10.2）μmol/L，两组比较差异具有统计学意义（P<0.05）。随着高血压分级的增高，患者血清ADMA水平明显增加，血清NO水平明显降低，I级、II级、III级患者间血清ADMA及NO水平比较差异显著（P<0.05）。 Pearson相关分析结果显示，观察组患者血清ADMA水平与SBP、DBP、LDL-C、HDL-C、TC、TG呈现正相关（P<0.05）。结论：血清ADMA水平与盐敏感性高血压的发生发展密切相关，对于病情判定和治疗具有一定价值。
目的：探討鹽敏感性高血壓患者血清非對稱二甲基精氨痠（asymmetric dimethylarginine，ADMA）的測定及其意義。方法：選取100例鹽敏感性高血壓患者為觀察組，選取100例健康體檢者為對照組。比較兩組血清ADMA水平、血清一氧化氮（nitric oxide， NO）水平；觀察不同分級的鹽敏感性高血壓患者血清ADMA水平差異；採用Pearson相關分析分析血清ADMA水平與血清三酰甘油（triglyceride， TG）、血清總膽固醇（total cholesterol， TC）、血清低密度脂蛋白膽固醇（low density lipoprotein cholesterol ， LDL-C）、血清高密度脂蛋白膽固醇（high density lipoprotein cholesterol， HDL-C）、收縮壓（systolic blood pressure，SBP）、舒張壓（diastolic blood pressure，DBP）的相關性。結果：觀察組血清ADMA和NO水平分彆為（3.8±0.8）μmol/L、（33.1±8.9）μmol/L；對照組血清ADMA和NO水平分彆為（2.3±0.7）μmol/L、（54.4±10.2）μmol/L，兩組比較差異具有統計學意義（P<0.05）。隨著高血壓分級的增高，患者血清ADMA水平明顯增加，血清NO水平明顯降低，I級、II級、III級患者間血清ADMA及NO水平比較差異顯著（P<0.05）。 Pearson相關分析結果顯示，觀察組患者血清ADMA水平與SBP、DBP、LDL-C、HDL-C、TC、TG呈現正相關（P<0.05）。結論：血清ADMA水平與鹽敏感性高血壓的髮生髮展密切相關，對于病情判定和治療具有一定價值。
목적：탐토염민감성고혈압환자혈청비대칭이갑기정안산（asymmetric dimethylarginine，ADMA）적측정급기의의。방법：선취100례염민감성고혈압환자위관찰조，선취100례건강체검자위대조조。비교량조혈청ADMA수평、혈청일양화담（nitric oxide， NO）수평；관찰불동분급적염민감성고혈압환자혈청ADMA수평차이；채용Pearson상관분석분석혈청ADMA수평여혈청삼선감유（triglyceride， TG）、혈청총담고순（total cholesterol， TC）、혈청저밀도지단백담고순（low density lipoprotein cholesterol ， LDL-C）、혈청고밀도지단백담고순（high density lipoprotein cholesterol， HDL-C）、수축압（systolic blood pressure，SBP）、서장압（diastolic blood pressure，DBP）적상관성。결과：관찰조혈청ADMA화NO수평분별위（3.8±0.8）μmol/L、（33.1±8.9）μmol/L；대조조혈청ADMA화NO수평분별위（2.3±0.7）μmol/L、（54.4±10.2）μmol/L，량조비교차이구유통계학의의（P<0.05）。수착고혈압분급적증고，환자혈청ADMA수평명현증가，혈청NO수평명현강저，I급、II급、III급환자간혈청ADMA급NO수평비교차이현저（P<0.05）。 Pearson상관분석결과현시，관찰조환자혈청ADMA수평여SBP、DBP、LDL-C、HDL-C、TC、TG정현정상관（P<0.05）。결론：혈청ADMA수평여염민감성고혈압적발생발전밀절상관，대우병정판정화치료구유일정개치。
Objective To evaluate the changes and characteristics of serum asymmetric dimethylarginine (ADMA) in salt-sensitive hypertension. Methods 100 patients with salt-sensitive hypertension were chose to observation group, 100 healthy subjects were chose to control group. The serum ADMA and nitric oxide (NO) were compared between the two groups. The serum ADMA were compared between different hypertension classification patients. Used the Pearson correlation analysis to analyze the correlation of serum ADMA , triglyceride(TG), total cholesterol(TC), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C), systolic blood pressure (SBP) and diastolic blood pressure (DBP). Results The serum ADMA and NO level of observation group respectively was(3.8±0.8)μmol/L and(33.1±8.9)μmol/L, those of control group respectively was(2.3±0.7)μmol/L and(54.4±10.2)μmol/L, the difference showed statistically significant(P<0.05). With hypertension classification increased, patients serum ADMA levels increased significantly, serum NO level decreased significantly, grade I, II and III patients serum ADMA and NO level was significant difference (P<0.05). Pearson correlation analysis results showed that, the serum ADMA level of observation group had positive correlation with SBP, DBP, LDL-C, HDL-C, TC and TG(P<0.05). Conclusion Serum ADMA level is closely related to the occurrence and and development of salt-sensitive hypertension, for judgement and treatment guidance has a certain value.
