CAJ | 학술논문

眼内炎是一种非常严重的致盲性疾病,一旦发生将造成急性视力下降甚至眼球萎缩.巨噬细胞是炎症反应的中心环节,炎症小体(inflammasome)是巨噬细胞中参与免疫反应的重要组成部分.鉴于巨噬细胞在非特异性免疫反应的诱发调节中起关键作用,如果明确眼内炎发生早期的巨噬细胞相关的抗感染免疫机制,可能为眼内炎的诊治开辟一条新的途径.
안내염시일충비상엄중적치맹성질병,일단발생장조성급성시력하강심지안구위축.거서세포시염증반응적중심배절,염증소체(inflammasome)시거서세포중삼여면역반응적중요조성부분.감우거서세포재비특이성면역반응적유발조절중기관건작용,여과명학안내염발생조기적거서세포상관적항감염면역궤제,가능위안내염적진치개벽일조신적도경.
Endophthalmitis is a serious disease causing blind,once it happens,acute loss of vision,even eyeball atrophy would occur.Macrophage is the central mechanism of the inflammation,and inflammasome is an important component of macrophages involved in the immune response.Since macrophages play a key role in the induced regulation of non-specific immune responses,it will benefit to the diagnosis and treatment of the catastrophic diseases when the anti-infection immune mechanisms of macrophages becomes clear in the very early stage of endophthalmitis.