国际眼科纵览
國際眼科縱覽
국제안과종람
OREIGN MEDICAL SCIENCES
2015年
2期
111-116
,共6页
脉络膜新生血管%转化生长因子-β%促血管生成因子
脈絡膜新生血管%轉化生長因子-β%促血管生成因子
맥락막신생혈관%전화생장인자-β%촉혈관생성인자
choroidal neovascularization%transforming growth factor-β%angiogenesis factor
转化生长因子-β(transforming growth factor-β,TGF-β)是具有生物活性的多肽,其与脉络膜新生血管形成(choroidal neovascularization,CNV)密切相关.Smad通路为TGF-β行使生物功能的经典通路.TGF-β信号通路在血管系统发育中起着重要作用.TGF-β通过与血管内皮细胞表面的ALK5和ALK1受体结合对其不同活化阶段进行调控,并通过Smad3和p38/MAPK两条信号通路来调控血管平滑肌的分化.CNV形成过程中TGF-β分泌升高,后者在CNV的形成和增生过程中起重要作用.干预TGF-β信号通路有可能成为CNV治疗的新靶点.
轉化生長因子-β(transforming growth factor-β,TGF-β)是具有生物活性的多肽,其與脈絡膜新生血管形成(choroidal neovascularization,CNV)密切相關.Smad通路為TGF-β行使生物功能的經典通路.TGF-β信號通路在血管繫統髮育中起著重要作用.TGF-β通過與血管內皮細胞錶麵的ALK5和ALK1受體結閤對其不同活化階段進行調控,併通過Smad3和p38/MAPK兩條信號通路來調控血管平滑肌的分化.CNV形成過程中TGF-β分泌升高,後者在CNV的形成和增生過程中起重要作用.榦預TGF-β信號通路有可能成為CNV治療的新靶點.
전화생장인자-β(transforming growth factor-β,TGF-β)시구유생물활성적다태,기여맥락막신생혈관형성(choroidal neovascularization,CNV)밀절상관.Smad통로위TGF-β행사생물공능적경전통로.TGF-β신호통로재혈관계통발육중기착중요작용.TGF-β통과여혈관내피세포표면적ALK5화ALK1수체결합대기불동활화계단진행조공,병통과Smad3화p38/MAPK량조신호통로래조공혈관평활기적분화.CNV형성과정중TGF-β분비승고,후자재CNV적형성화증생과정중기중요작용.간예TGF-β신호통로유가능성위CNV치료적신파점.
Transforming growth factor-β (TGF-β),a polypeptide,has been shown to have biological function and may be closely related to the choroidal neovascularization (CNV) formation.Smads pathway is the classic signaling pathway when TGF-β elicits its pleiotropic effects.TGF-β signaling plays an important role in the development of the vascular system.It can regulate the activation of endothelial cells in different stages by binding to its specific receptors ALK5 and ALK1,and modulate the differentiation of smooth muscle cells through the Smad3 and p38/MAPK signaling pathways.TGF-β secretion is increased during the CNV formation,which play an important role in the CNV process.TGF-β signaling pathway intervention may become a new target for the treatment of CNV.Intervention of TGF-β signal pathway may become a new target for CNV treatment.
