CAJ | 학술논문

目的探讨前中颅底神经内分泌癌的治疗方式及预后.方法回顾性分析首都医科大学宣武医院2006年11月至2014年6月收治的14例前中颅底神经内分泌癌患者的临床资料.所有患者均行内镜经鼻手术,4例行单纯手术治疗,2例术前行放疗,1例术前行化疗,1例术后行放疗,6例术后行放化疗.采用Kaplan-Meier法进行生存率分析.结果 12例患者肿瘤达到全切,2例次全切除,均无手术并发症.其中分化好的神经内分泌癌3例,中分化2例,小细胞神经内分泌癌9例.术后随访6 ～97个月,中位随访时间36个月,死亡3例,失访1例,5年生存率64.3％.结论针对不同病理类型采取单纯内镜经鼻手术或以内镜手术为主的综合治疗可能是前中颅底神经内分泌癌可行的治疗方式.
목적 탐토전중로저신경내분비암적치료방식급예후.방법 회고성분석수도의과대학선무의원2006년11월지2014년6월수치적14례전중로저신경내분비암환자적림상자료.소유환자균행내경경비수술,4례행단순수술치료,2례술전행방료,1례술전행화료,1례술후행방료,6례술후행방화료.채용Kaplan-Meier법진행생존솔분석.결과 12례환자종류체도전절,2례차전절제,균무수술병발증.기중분화호적신경내분비암3례,중분화2례,소세포신경내분비암9례.술후수방6 ～97개월,중위수방시간36개월,사망3례,실방1례,5년생존솔64.3％.결론 침대불동병리류형채취단순내경경비수술혹이내경수술위주적종합치료가능시전중로저신경내분비암가행적치료방식.
Objective To investigate the optimal treatment strategy with endoscopic endonasal approach (EEA) and the prognostic factors of anterior and middle skull base neuroendocrine carcinoma (NEC).Method Fourteen patients with anterior and/or middle skull base NEC,admitted to Xuanwu Hospital between November 2006 and June 2014,were reviewed retrospectively.All patients were treated with EEA.Four cases received surgery onle.Two cases received radiotherapy and one case received chemotherapy before surgery.One case received adjuvant radiotherapy and 6 cases received chemoradiation after surgery.Survival analysis was performed by Kaplan-Meier method.Result Complete resection was achieved in 12 cases,while subtotal resection was achieved in 2 cases.There was no surgical complication.Three cases were diagnosed as well-differentiated NEC,2 cases were moderately differentiated NEC and 9 cases were small cell NEC.The patients were followed up for 6 to 97 months.Three patients died and one patient lost to follow-up.The 5-year survival rate in this group was 64.3％.Conclusion Pure EEA or EEA combined with multimodality therapy,which was applied depending on the pathological type,was a feasible treatment strategy for anterior and middle skull base NEC.