CAJ | 학술논문

目的：探讨芪明颗粒联合普拉洛芬滴眼液对糖尿病（DM）白内障超声乳化术（简称超乳术）后黄斑水肿的作用。方法将医院2012年6月至2014年5月行白内障超乳术的DM患者100例（100只眼）随机分为治疗组和对照组，各50例（50只眼）。对照组患者术后应用妥布霉素地塞米松滴眼液治疗，治疗组患者在对照组基础上应用普拉洛芬滴眼液并口服芪明颗粒治疗，均治疗4周。分别于术前，术后1周、1个月及3个月对患者行眼部常规检查，包括最佳矫正视力（BCVA）、眼压、眼底检查，并利用光学相干断层扫描（OCT）检查测量黄斑中心凹厚度。结果两组患者术后1周、1个月及3个月BCVA均明显恢复（ P﹤0.01），术后1个月及3个月治疗组患者BCVA的恢复情况显著优于对照组（ P﹤0.05）；所有患者术后眼压均在正常值范围内；术后3个月，治疗组黄斑中心凹厚度显著低于对照组（ P﹤0.05）；术后3个月对照组黄斑水肿发病率为16.00%，治疗组黄斑水肿发病率为4.00%，较对照组显著降低（ P﹤0.05）。结论DM患者白内障超乳术后于妥布霉素地塞米松滴眼液基础上加用芪明颗粒联合普拉洛芬滴眼液，可防止术后黄斑中心凹厚度增加，有效减少术后黄斑水肿的发生率。
목적：탐토기명과립연합보랍락분적안액대당뇨병（DM）백내장초성유화술（간칭초유술）후황반수종적작용。방법장의원2012년6월지2014년5월행백내장초유술적DM환자100례（100지안）수궤분위치료조화대조조，각50례（50지안）。대조조환자술후응용타포매소지새미송적안액치료，치료조환자재대조조기출상응용보랍락분적안액병구복기명과립치료，균치료4주。분별우술전，술후1주、1개월급3개월대환자행안부상규검사，포괄최가교정시력（BCVA）、안압、안저검사，병이용광학상간단층소묘（OCT）검사측량황반중심요후도。결과량조환자술후1주、1개월급3개월BCVA균명현회복（ P﹤0.01），술후1개월급3개월치료조환자BCVA적회복정황현저우우대조조（ P﹤0.05）；소유환자술후안압균재정상치범위내；술후3개월，치료조황반중심요후도현저저우대조조（ P﹤0.05）；술후3개월대조조황반수종발병솔위16.00%，치료조황반수종발병솔위4.00%，교대조조현저강저（ P﹤0.05）。결론DM환자백내장초유술후우타포매소지새미송적안액기출상가용기명과립연합보랍락분적안액，가방지술후황반중심요후도증가，유효감소술후황반수종적발생솔。
Objective To investigate the effect of Qiming Granules combined with Pranopulin Eye Drops on macular edema after pha-coemulsification in diabetes mellitus(DM) patients with cataract. Methods 100 DM patients with cataract(100 eyes) treated with pha-coemulsification in the hospital from June 2012 to May 2014 were randomly divided into the treatment group and the control group,50 cases(50 eyes)in each group. The control group was treated with Tobramycin and Dexamethasone Eye Drops after operation,4 times a day;on this basis the treatment group used Pranopulin Eye Drops,4 times a day and oral Qiming Granules,3 times a day. The efficacy after 4-week treatment was observed in the two groups. The routine ophthalmic examination including best corrected visual acuity (BCVA),intraocular pressure and fundus examination and optical coherence tomography(OCT) for detecting and measuring the central foveal thickness were performed before operation and at 1 week,1,3 months after operation. Results BCVA at postoperative 1 week,1, 3 months in the two groups was improved significantly( P ﹤ 0. 01),the BCVA improvement at postoperative 1,3 months in the treat-ment group was better than that in the control group( P ﹤ 0. 05);the postoperative intraocular pressure of all patients were in the nor-mal range. The central foveal thickness at postoperative 3 months in the treatment group was significantly lower than that in the control group in 3 month( P ﹤ 0. 05). The incidence rate of macular edema at postoperative 3 months in the treatment group was 4. 00%, which was markedly lower than 16. 00% in the control group( P ﹤ 0. 05). Conclusion Adding Qiming Granules combined with Pra-nopulin Eye Drops on the basis of Tobramycin and Dexamethasone Eye Drops after phacoemulsification in DM patients can prevent the increase of postoperative central foveal thickness and effectively reduce the incidence rate of macular edema.