中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
10期
62-63
,共2页
复方醋酸棉酚片%溶出度%分光光度法
複方醋痠棉酚片%溶齣度%分光光度法
복방작산면분편%용출도%분광광도법
Compound Gossypol Acetate Tablets%dissolution rate%spectrophotometry
目的：建立测定复方醋酸棉酚片溶出度的方法。方法采用0.3%聚山梨酯的磷酸钠缓冲液（pH=8.0）1000 mL为溶出介质，溶出方法为桨法，转速为75 r/min。结果复方醋酸棉酚片溶出度的线性回归方程为 Y=0.0216 X-0.0054（ r=1，n=5），线性范围为5.10~25.50μg/mL；平均回收率为99.56%，RSD=0.51%（ n=9）。结论该方法简便快捷、回收率高、结果准确，可作为复方醋酸棉酚片溶出度的测定方法。
目的：建立測定複方醋痠棉酚片溶齣度的方法。方法採用0.3%聚山梨酯的燐痠鈉緩遲液（pH=8.0）1000 mL為溶齣介質，溶齣方法為槳法，轉速為75 r/min。結果複方醋痠棉酚片溶齣度的線性迴歸方程為 Y=0.0216 X-0.0054（ r=1，n=5），線性範圍為5.10~25.50μg/mL；平均迴收率為99.56%，RSD=0.51%（ n=9）。結論該方法簡便快捷、迴收率高、結果準確，可作為複方醋痠棉酚片溶齣度的測定方法。
목적：건립측정복방작산면분편용출도적방법。방법채용0.3%취산리지적린산납완충액（pH=8.0）1000 mL위용출개질，용출방법위장법，전속위75 r/min。결과복방작산면분편용출도적선성회귀방정위 Y=0.0216 X-0.0054（ r=1，n=5），선성범위위5.10~25.50μg/mL；평균회수솔위99.56%，RSD=0.51%（ n=9）。결론해방법간편쾌첩、회수솔고、결과준학，가작위복방작산면분편용출도적측정방법。
Objective To establish a determination method of the dissolution rate of Compound Gossypol Acetate Tablets. Methods 0. 3% polysorbate sodium phosphate buffer(pH=8. 0)1 000 mL was adopted as the dissolution medium. The dissolution method was the paddle method. The rotation speed was 75 r/min. Results The linear equation of dissolution rate of Compound Gossypol Acetate Tablets was Y=0. 021 6 X-0. 005 4( r=1,n=5),the linear range was 5. 10-25. 50 μg/mL. The average recovery rate was 99. 56%, RSD=0. 51%( n=9). Conclusion This method is simple,convenient,and accurate with high recovery rate,and serves as the determi-nation method of dissolution rate of Compound Gossypol Acetate Tablets.
