CAJ | 학술논문

目的：观察活血益气补肾方对老年髋关节置换术后血液流变学参数及内皮型一氧化氮合酶（ endo-thelial nitric oxide synthase， eNOS）活性的影响。方法：将符合标准的60例行髋关节置换术患者随机分为3组，每组20例。中医治疗组服用活血益气补肾方，肝素治疗组皮下注射依诺肝素，对照组服用阿司匹林肠溶片，检测3组术前、术后第1、10天血液eNOS、一氧化氮（ nitric oxide， NO）及血液流变学的变化。结果：中医治疗组患者术后1 d血液eNOS、NO含量、全血黏度（ whole blood viscosity，WBV）、血浆黏度（ plasma viscosity，PV）、红细胞比积（ hem-atocrit，HCT）、红细胞聚集系数（ erythrocyte aggregation index，EAI）、刚性指数（ index of rigidity，IR）、红细胞变形指数（erythrocyte deformation index，EDI）和红细胞电泳时间（erythrocyte electrophoresis time，EET）与其余2组比较，差异无统计学意义（ P＞0.05），术后10 d中医治疗组和对照组比较，血液eNOS和NO浓度明显高于对照组，血液流变学指标明显改善；中医治疗组和肝素治疗组比较，上述指标差异不显著（ P＞0.05）。结论：活血益气补肾方能有效提高老年髋关节置换术后血液eNOS和NO浓度，改善血液流变状态。
목적：관찰활혈익기보신방대노년관관절치환술후혈액류변학삼수급내피형일양화담합매（ endo-thelial nitric oxide synthase， eNOS）활성적영향。방법：장부합표준적60례행관관절치환술환자수궤분위3조，매조20례。중의치료조복용활혈익기보신방，간소치료조피하주사의낙간소，대조조복용아사필림장용편，검측3조술전、술후제1、10천혈액eNOS、일양화담（ nitric oxide， NO）급혈액류변학적변화。결과：중의치료조환자술후1 d혈액eNOS、NO함량、전혈점도（ whole blood viscosity，WBV）、혈장점도（ plasma viscosity，PV）、홍세포비적（ hem-atocrit，HCT）、홍세포취집계수（ erythrocyte aggregation index，EAI）、강성지수（ index of rigidity，IR）、홍세포변형지수（erythrocyte deformation index，EDI）화홍세포전영시간（erythrocyte electrophoresis time，EET）여기여2조비교，차이무통계학의의（ P＞0.05），술후10 d중의치료조화대조조비교，혈액eNOS화NO농도명현고우대조조，혈액류변학지표명현개선；중의치료조화간소치료조비교，상술지표차이불현저（ P＞0.05）。결론：활혈익기보신방능유효제고노년관관절치환술후혈액eNOS화NO농도，개선혈액류변상태。
AIM:To observe the effects of Huoxue-Yiqi-Bushen prescription on the hemorrheological parame-ters and endothelial nitric oxide synthase ( eNOS) activity in the aged patients with hip arthroplasty at postoperative period. METHODS:The patients ( n=60) operated by the same group of doctors were randomly divided into traditional Chinese medicine ( TCM) group, low-molecular-weight heparin ( LMWH) group and control group.Postoperative patients in TCM group were administrated with Huoxue-Yiqi-Bushen prescription.In LMWH group, 20 patients received LMWH postopera-tively.The patients in control group took aspirin enteric-coated tablets.The eNOS activity, nitric oxide (NO) content and hemorrheological parameters were observed before operation and 1 d and 10 d after operation.RESULTS: No significant difference of eNOS activity, NO content, whole blood viscosity (WBV), plasma viscosity (PV), hematocrit (HCT), erythrocyte aggregation index ( EAI) , index of rigidity ( IR) , erythrocyte deformation index ( EDI) and erythrocyte electro-phoresis time (EET) between 3 groups 1 d after operation was found, while significant difference (P<0.01) appeared be-tween TCM group and control group 10 d after operation.CONCLUSION:Huoxue-Yiqi-Bushen prescription can effective-ly increase eNOS and NO levels and improve hemorrheological parameters at postoperative period in aged patients with hip arthroplasty.