中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2015年
10期
38-39
,共2页
度洛西汀%认知干预%癌症%抑郁%临床疗效%生活质量
度洛西汀%認知榦預%癌癥%抑鬱%臨床療效%生活質量
도락서정%인지간예%암증%억욱%림상료효%생활질량
duloxetine%cognitive intervention%cancer%depression%clinical curative effect%quality of life
目的：探讨度洛西汀联合认知干预对癌症患者抑郁程度和生活质量的影响。方法选择医院2013年6月至2014年8月收治的恶性肿瘤伴抑郁的患者60例，随机分为对照组和观察组，各30例。两组患者均接受常规抗肿瘤治疗，对照组患者加用认知干预，观察组患者在对照组基础上加用度洛西汀肠溶片，两组均治疗8周。采用汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）评定疗效，观察生存质量及不良反应的发生情况。结果观察组总有效率为86.67%，显著高于对照组的46.67%（ P﹤0.05）。与治疗前比较，两组患者的HAMD和HAMA评分均显著下降（ P﹤0.05），且观察组下降更显著（ P﹤0.05）；两组患者在心理、独立性和社会关系3个领域均得到改善，且观察组改善更显著（ P﹤0.05）；对照组患者在生理领域方面改善不明显，但观察组有显著改善（ P﹤0.05）；两组患者在环境领域均无明显改善（ P﹥0.05）；观察组不良反应总发生率为46.67%，对照组为43.33%，组间比较，差异无统计学意义（ P﹥0.05）；结论度洛西汀联合认知干预治疗癌症伴发抑郁疗效好，能显著改善患者的生活质量，且安全性好，值得推广。
目的：探討度洛西汀聯閤認知榦預對癌癥患者抑鬱程度和生活質量的影響。方法選擇醫院2013年6月至2014年8月收治的噁性腫瘤伴抑鬱的患者60例，隨機分為對照組和觀察組，各30例。兩組患者均接受常規抗腫瘤治療，對照組患者加用認知榦預，觀察組患者在對照組基礎上加用度洛西汀腸溶片，兩組均治療8週。採用漢密爾頓抑鬱量錶（HAMD）、漢密爾頓焦慮量錶（HAMA）評定療效，觀察生存質量及不良反應的髮生情況。結果觀察組總有效率為86.67%，顯著高于對照組的46.67%（ P﹤0.05）。與治療前比較，兩組患者的HAMD和HAMA評分均顯著下降（ P﹤0.05），且觀察組下降更顯著（ P﹤0.05）；兩組患者在心理、獨立性和社會關繫3箇領域均得到改善，且觀察組改善更顯著（ P﹤0.05）；對照組患者在生理領域方麵改善不明顯，但觀察組有顯著改善（ P﹤0.05）；兩組患者在環境領域均無明顯改善（ P﹥0.05）；觀察組不良反應總髮生率為46.67%，對照組為43.33%，組間比較，差異無統計學意義（ P﹥0.05）；結論度洛西汀聯閤認知榦預治療癌癥伴髮抑鬱療效好，能顯著改善患者的生活質量，且安全性好，值得推廣。
목적：탐토도락서정연합인지간예대암증환자억욱정도화생활질량적영향。방법선택의원2013년6월지2014년8월수치적악성종류반억욱적환자60례，수궤분위대조조화관찰조，각30례。량조환자균접수상규항종류치료，대조조환자가용인지간예，관찰조환자재대조조기출상가용도락서정장용편，량조균치료8주。채용한밀이돈억욱량표（HAMD）、한밀이돈초필량표（HAMA）평정료효，관찰생존질량급불량반응적발생정황。결과관찰조총유효솔위86.67%，현저고우대조조적46.67%（ P﹤0.05）。여치료전비교，량조환자적HAMD화HAMA평분균현저하강（ P﹤0.05），차관찰조하강경현저（ P﹤0.05）；량조환자재심리、독립성화사회관계3개영역균득도개선，차관찰조개선경현저（ P﹤0.05）；대조조환자재생리영역방면개선불명현，단관찰조유현저개선（ P﹤0.05）；량조환자재배경영역균무명현개선（ P﹥0.05）；관찰조불량반응총발생솔위46.67%，대조조위43.33%，조간비교，차이무통계학의의（ P﹥0.05）；결론도락서정연합인지간예치료암증반발억욱료효호，능현저개선환자적생활질량，차안전성호，치득추엄。
Objective To investigate the influence of Duloxetine combined with the cognitive intervention on the depression degree and the quality of life in patients with cancer. Methods Totally 60 patients with malignant tumor complicated with depression in the hospi-tal from June 2013 to August 2014 were selected and randomly divided into the control group and the observation group,30 cases in each group. The two groups received the conventional anti-tumor treatment. The control group was added with the cognitive interven-tion,while on this basis the observation group was added with Duloxetine Enteric-Coated Tablet. The two groups were treated for 8 weeks. The Hamilton depression scale(HAMD)and the Hamilton anxiety scale(HAMA)were adopted to evaluate the curative effects in the two groups. The survival quality and the occurrence situation of adverse reactions were observed. Results The total effective rate in the observation group was 86. 67%,which was significantly higher than 46. 67% in the control group( P ﹤ 0. 05). Compared with before treatment,the HAMA and HAMD scores after treatment in the two groups were significantly decreased( P ﹤ 0. 05),moreover the de-scend amplitude in the observation group was more significant than that in the control group( P ﹤ 0. 05). The three fields of mentality, independence and social relationship in the two groups were improved,moreover the improvement degree in the observation group was greater than that in the control group( P ﹤ 0. 05);the control group had no obvious improvement in the physiological field,but the ob-servation group got significant improvement in this field( P ﹤ 0. 05). The two groups had no remarkable improvement in the environment field ( P ﹥ 0. 05);the total occurrence rate of adverse reactions was 46. 67% in the observation group and 43. 33% in the control group without statistical difference between them( P ﹥ 0. 05). Conclusion Duloxetine combined with the cognitive intervention in treat-ing cancer complicating depression has better clinical effect,can significantly improve the patient's quality of life with good safety,and is worth of clinical promotion.
