基层医学论坛
基層醫學論罈
기층의학론단
PUBLIC MEDICAL FORUM MAGAZINE
2015年
15期
2017-2019
,共3页
宫颈鳞癌%宫颈上皮内瘤变%缺氧诱导因子-1α%survivin%免疫组织化学
宮頸鱗癌%宮頸上皮內瘤變%缺氧誘導因子-1α%survivin%免疫組織化學
궁경린암%궁경상피내류변%결양유도인자-1α%survivin%면역조직화학
Cervical quamous cell carcinoma%Cervical intraepithelial neoplasias( CIN )%Hypoxia-induced factor-1α%Survivin%Immunohistochemistry
目的：研究缺氧诱导因子-1α（HIF-1α）和生存素蛋白（survivin）在正常宫颈组织、宫颈上皮内瘤变组织（CIN）及宫颈鳞癌组织中的表达及意义。方法应用免疫组化的方法检测HIF-1α、survivin在宫颈鳞癌标本74例、CIN标本40例、正常宫颈标本24例中的表达情况。分析了两者与宫颈鳞癌病理学分级、临床分期及淋巴结转移的关系。结果 HIF-1α、survivin两种蛋白在正常宫颈组织中不表达，但在CIN组和宫颈鳞癌组中阳性表达率逐渐升高；HIF-1α、survivin阳性表达率与宫颈鳞状细胞癌的病理分级，临床分期，淋巴结转移呈正相关；在宫颈癌组织中HIF-1α与survivin的表达程度呈正相关。结论缺氧诱导因子-1α与survivin的阳性表达对恶性肿瘤的发展起着重要作用，对两个指标的联合检测有助于评估肿瘤的恶性程度及判断预后。
目的：研究缺氧誘導因子-1α（HIF-1α）和生存素蛋白（survivin）在正常宮頸組織、宮頸上皮內瘤變組織（CIN）及宮頸鱗癌組織中的錶達及意義。方法應用免疫組化的方法檢測HIF-1α、survivin在宮頸鱗癌標本74例、CIN標本40例、正常宮頸標本24例中的錶達情況。分析瞭兩者與宮頸鱗癌病理學分級、臨床分期及淋巴結轉移的關繫。結果 HIF-1α、survivin兩種蛋白在正常宮頸組織中不錶達，但在CIN組和宮頸鱗癌組中暘性錶達率逐漸升高；HIF-1α、survivin暘性錶達率與宮頸鱗狀細胞癌的病理分級，臨床分期，淋巴結轉移呈正相關；在宮頸癌組織中HIF-1α與survivin的錶達程度呈正相關。結論缺氧誘導因子-1α與survivin的暘性錶達對噁性腫瘤的髮展起著重要作用，對兩箇指標的聯閤檢測有助于評估腫瘤的噁性程度及判斷預後。
목적：연구결양유도인자-1α（HIF-1α）화생존소단백（survivin）재정상궁경조직、궁경상피내류변조직（CIN）급궁경린암조직중적표체급의의。방법응용면역조화적방법검측HIF-1α、survivin재궁경린암표본74례、CIN표본40례、정상궁경표본24례중적표체정황。분석료량자여궁경린암병이학분급、림상분기급림파결전이적관계。결과 HIF-1α、survivin량충단백재정상궁경조직중불표체，단재CIN조화궁경린암조중양성표체솔축점승고；HIF-1α、survivin양성표체솔여궁경린상세포암적병리분급，림상분기，림파결전이정정상관；재궁경암조직중HIF-1α여survivin적표체정도정정상관。결론결양유도인자-1α여survivin적양성표체대악성종류적발전기착중요작용，대량개지표적연합검측유조우평고종류적악성정도급판단예후。
ObjectiveThis paper aimed to study the expression of HIF-1αand survivin in normal cervical tissue, cervical intraepithelial neoplasia(CIN)and cervical squamous cancer tissue.MethodsThe expression levels of HIF-1αand survivin in 74 cases of cervical squamous cancer specimens and 40 cases of cervical intiaepithelial neoplasia specimens and 24 cases of normal cervixs specimens were detected by immunohistochemical methods.Results HIF-1α,surviving is not expressed in normal cervical tissue,but HIF-1α、survivin were positive in cervical cancer, cervical intraepithelial neoplasia;HIF-1α、survivin expression in cervical carcinoma was significantly higher than cervical intraepithelial neoplasia group.HIF-1α、survivin in CIN tissue was significantly higher than the expression of normal cervical mucosa group;HIF-1αand survivin expression in cervical cancer was positively correlated.Conclusion HIF-1αand survivin were collaborative in progression of cervical cancer;Combined detection of the expression of both is useful for evaluating malignancy and predicting prognosis of cervical squamous cancer.
