CAJ | 학술논문

目的：观察奥沙利铂与卡培他滨联合治疗晚期结肠癌的临床疗效及不良反应。方法选取2013年1月至2013年12月收治的80例晚期结肠癌患者，随机均分为两组，对照组采用奥沙利铂联合5－氟尿嘧啶方案，试验组采用奥沙利铂联合卡培他滨方案。观察并记录两组患者疗效及安全性。结果两组患者各完成3个疗程的化学治疗（简称化疗）后，试验组临床总有效率达72.50%，效果明显好于对照组的40.00%，且差异具有统计学意义（ P＜0.05）；试验组患者出现口腔黏膜炎、白细胞减少及肝功能异常等不良反应明显少于对照组，差异具有统计学意义（ P＜0.05）。结论奥沙利铂与卡培他滨联合应用治疗晚期结肠癌临床疗效较好，不良反应较少，值得推广。
목적：관찰오사리박여잡배타빈연합치료만기결장암적림상료효급불량반응。방법선취2013년1월지2013년12월수치적80례만기결장암환자，수궤균분위량조，대조조채용오사리박연합5－불뇨밀정방안，시험조채용오사리박연합잡배타빈방안。관찰병기록량조환자료효급안전성。결과량조환자각완성3개료정적화학치료（간칭화료）후，시험조림상총유효솔체72.50%，효과명현호우대조조적40.00%，차차이구유통계학의의（ P＜0.05）；시험조환자출현구강점막염、백세포감소급간공능이상등불량반응명현소우대조조，차이구유통계학의의（ P＜0.05）。결론오사리박여잡배타빈연합응용치료만기결장암림상료효교호，불량반응교소，치득추엄。
Objective To observe the clinical efficacy and adverse reactions of the combination application of oxaliplatin and capecitabine in treating advanced colon cancer. Methods 80 cases of advanced colon cancer in our hospital from January to December 2013 were selected and divided into 2 groups at random. The control group was treated with oxaliplatin combined with 5-FU, while the experimental group was given the combination therapy of oxaliplatin and capecitabine. The efficacy and adverse reactions were recorded and compared between the two groups. Results The total effective rate after 3 course of treatment in the experimental group was 72. 50%, which was better than 40. 00% in the control group, the difference was statistically significant ( P < 0. 05 );the occurrence of oral mucositis, leukopenia and liver function abnormality in the experimental group was significantly decreased compared with the control group, the difference was statistically significant ( P < 0. 05 ) . Conclusion The combination application of oxaliplatin and capecitabine has better therapeutic effect and fewer adverse reactions for treating advanced colon cancer, which is worthy of being promoted in clinic.