医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2015年
2期
30-32,67
,共4页
妊娠中期%血清标记物%唐氏综合征%产前筛查
妊娠中期%血清標記物%唐氏綜閤徵%產前篩查
임신중기%혈청표기물%당씨종합정%산전사사
Mid trimester of pregnancy%Serum markers%Down syndrome%Prenatal screening
目的：研究分析妊娠中期血清标记物在产前筛查唐氏综合症的意义。方法：择取2012.10-2013.10期间在我院应用实践分辨免疫荧光法检测的2468例孕15-20+6周的孕妇，均进行血清Free-β-HCG、AFP标记物含量检测，并结合孕妇的年龄、孕周时间、单双胎、吸烟史、体质量、是否伴有糖尿病、既往有无异常妊娠史等因素，利用Life Cycle 3.0版系统进行风险评估。结果：本组2468例妊娠妇女中，筛出染色体异常的138例高风险妊娠孕妇，其中34例孕妇进行了羊膜腔穿刺产前检查，诊断为唐氏综合症（Down syndrome，DS）者8例，18-三体综合症者1例，其他胎儿染色体异常者4例。DS 胎儿母体血液内AFP、游离雌三醇含量明显低于正常孕妇；Free-β-HCG 含量明显高于正常孕妇，差异P<0.05有统计学意义。18-三体胎儿母体血液内AFP、游离雌三醇、Free-β-HCG含量明显低于正常孕妇，差异P<0.05有统计学意义。结论：妊娠中期血清内标记物检查可作为预测胎儿染色体畸形的重要指标，通过产前诊断及时采取有效措施，可以明显减少胎儿出生缺陷，有助于优生工作的进行。
目的：研究分析妊娠中期血清標記物在產前篩查唐氏綜閤癥的意義。方法：擇取2012.10-2013.10期間在我院應用實踐分辨免疫熒光法檢測的2468例孕15-20+6週的孕婦，均進行血清Free-β-HCG、AFP標記物含量檢測，併結閤孕婦的年齡、孕週時間、單雙胎、吸煙史、體質量、是否伴有糖尿病、既往有無異常妊娠史等因素，利用Life Cycle 3.0版繫統進行風險評估。結果：本組2468例妊娠婦女中，篩齣染色體異常的138例高風險妊娠孕婦，其中34例孕婦進行瞭羊膜腔穿刺產前檢查，診斷為唐氏綜閤癥（Down syndrome，DS）者8例，18-三體綜閤癥者1例，其他胎兒染色體異常者4例。DS 胎兒母體血液內AFP、遊離雌三醇含量明顯低于正常孕婦；Free-β-HCG 含量明顯高于正常孕婦，差異P<0.05有統計學意義。18-三體胎兒母體血液內AFP、遊離雌三醇、Free-β-HCG含量明顯低于正常孕婦，差異P<0.05有統計學意義。結論：妊娠中期血清內標記物檢查可作為預測胎兒染色體畸形的重要指標，通過產前診斷及時採取有效措施，可以明顯減少胎兒齣生缺陷，有助于優生工作的進行。
목적：연구분석임신중기혈청표기물재산전사사당씨종합증적의의。방법：택취2012.10-2013.10기간재아원응용실천분변면역형광법검측적2468례잉15-20+6주적잉부，균진행혈청Free-β-HCG、AFP표기물함량검측，병결합잉부적년령、잉주시간、단쌍태、흡연사、체질량、시부반유당뇨병、기왕유무이상임신사등인소，이용Life Cycle 3.0판계통진행풍험평고。결과：본조2468례임신부녀중，사출염색체이상적138례고풍험임신잉부，기중34례잉부진행료양막강천자산전검사，진단위당씨종합증（Down syndrome，DS）자8례，18-삼체종합증자1례，기타태인염색체이상자4례。DS 태인모체혈액내AFP、유리자삼순함량명현저우정상잉부；Free-β-HCG 함량명현고우정상잉부，차이P<0.05유통계학의의。18-삼체태인모체혈액내AFP、유리자삼순、Free-β-HCG함량명현저우정상잉부，차이P<0.05유통계학의의。결론：임신중기혈청내표기물검사가작위예측태인염색체기형적중요지표，통과산전진단급시채취유효조시，가이명현감소태인출생결함，유조우우생공작적진행。
Objective:To study the analysis of second trimester maternal serum marker for prenatal screening of Down's syndrome and the significance. Methods:The selection of 2012.10-2013.10 in our hospital during the application of resolution immunofluorescence assay was used to detect 2468 cases of 15-20+6 weeks pregnant women were detected serum Free-, P-HCG, AFP markers and content, combined with maternal age, gestational weeks, single twins, smoking history, body mass, whether patients with diabetes, previous factors without abnormal pregnancy history, the use of Life Cycle 3 version of the system risk assessment.Results:The 2468 cases of pregnant women, screening out the abnormal chromosome 138 cases of pregnant women with high risk pregnancy, including 34 cases of pregnant women were amniocentesis antenatal examination, diagnosis of Down syndrome (English referred to as DS) in 8 cases, 1 cases of trisomy 18-syndrome, 4 cases of other fetal chromosomal abnormalities. DS maternal fetal blood AFP, free three female alcohol content was significantly lower than that in normal pregnant women;Free-beta-HCG was significantly higher than that of normal pregnant women, the difference was statistical y significant P<0.05. Trisomy 18-fetal maternal blood AFP, free three female alcohol, Free-beta-HCG was obviously lower than that of normal pregnant women, the difference was statistical y significant P<0.05. Conclusions:The second trimester serum marker examination can be used as an important index prediction of fetal chromosomal abnormalities, and take effective measures in a timely manner through the prenatal diagnosis, can significantly reduce the birth defects, to help students work.
