CAJ | 학술논문

目的：观察伏立康唑治疗肺部侵袭性真菌感染的疗效与安全性。方法选取西南医院呼吸内科侵袭性真菌感染患者78例，均给予伏立康唑治疗，观察症状体征、实验室及微生物指标，并对该药疗效、细菌清除率及安全性进行分析评价。结果可评价疗效的患者中，伏立康唑对真菌感染的清除率为83.33%，治愈率为38.46%，总有效率为92.31%；不良反应有失眠16例（20.51%），抑郁3例（3.85%），眩晕6例（7.69%），转氨酶升高4例（5.13%），恶心呕吐4例(5.13%)，血压升高2例（2.56%），球结膜水肿1例（1.28%），经对症治疗后均好转。结论伏立康唑为新型抗真菌药物，是目前治疗肺部侵袭性真菌感染的较佳临床药物，具有疗效高、安全等特点，值得临床推广。
목적：관찰복립강서치료폐부침습성진균감염적료효여안전성。방법선취서남의원호흡내과침습성진균감염환자78례，균급여복립강서치료，관찰증상체정、실험실급미생물지표，병대해약료효、세균청제솔급안전성진행분석평개。결과가평개료효적환자중，복립강서대진균감염적청제솔위83.33%，치유솔위38.46%，총유효솔위92.31%；불량반응유실면16례（20.51%），억욱3례（3.85%），현훈6례（7.69%），전안매승고4례（5.13%），악심구토4례(5.13%)，혈압승고2례（2.56%），구결막수종1례（1.28%），경대증치료후균호전。결론복립강서위신형항진균약물，시목전치료폐부침습성진균감염적교가림상약물，구유료효고、안전등특점，치득림상추엄。
Objective To evaluate the effect and safety of voriconazole in treating the patients with invasive pulmonary fungal infection. Methods 78 patients with invasive fungal infections in the respiratory department of our hospital were selected and given the voricona-zole treatment. The symptoms and signs, laboratory and microbial indicators, curative effect, microbial clearance rate and safety of the drug were analyzed and evaluated. Results In the patients with evaluable effect, the mycological clearance rate, curative rate and total effec-tive rate were 83. 33%, 38. 46% and 92. 31%, respectively; The adverse reactions included 16 cases ( 20. 51% ) of insomnia, 3 cases ( 3. 85%) of depression, 6 cases ( 7. 69%) of vertigo, 4 cases ( 5. 13%) of aminotransferase increase, 2 cases ( 2. 56%) of blood pres-sure elevation and 1 case ( 1. 28% ) of chemosis and were improved by the symptomatic treatment. Conclusion Voriconazole is a new type antifungal drug. As the optimal clinical drug for treating pulmonary invasive fungal infection, voriconazole has the characteristics of high efficacy and safety and is worthy of being clinically promoted.