CAJ | 학술논문

目的：评价奥卡西平治疗原发性三叉神经痛的临床疗效及对患者睡眠质量的改善作用。方法将120例原发性三叉神经痛患者随机分为两组，各60例。治疗组采用奥卡西平治疗，对照组采用卡马西平治疗，治疗12周。对患者疼痛视觉模拟评分( VAS )、匹兹堡睡眠指数（PSQI）、不良反应发生率进行评估。结果治疗12周后，治疗组总有效率为88.33%，明显高于对照组的76.67%( P＜0.05)；两组患者睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间活动障碍，PSQI总分均较治疗前降低( P＜0.05)，但治疗组患者睡眠质量、入睡时间、睡眠时间、睡眠效率、日间活动障碍及 PSQI 总分改善优于对照组( P＜0.05)；治疗组不良反应发生率为8.33%，显著低于对照组的16.67%( P＜0.05)。结论奥卡西平作为治疗原发性三叉神经痛的一线用药，镇痛效果佳、临床疗效优、不良反应率低，且可有效改善患者睡眠质量，值得临床推广。
목적：평개오잡서평치료원발성삼차신경통적림상료효급대환자수면질량적개선작용。방법장120례원발성삼차신경통환자수궤분위량조，각60례。치료조채용오잡서평치료，대조조채용잡마서평치료，치료12주。대환자동통시각모의평분( VAS )、필자보수면지수（PSQI）、불량반응발생솔진행평고。결과치료12주후，치료조총유효솔위88.33%，명현고우대조조적76.67%( P＜0.05)；량조환자수면질량、입수시간、수면시간、수면효솔、수면장애、최면약물、일간활동장애，PSQI총분균교치료전강저( P＜0.05)，단치료조환자수면질량、입수시간、수면시간、수면효솔、일간활동장애급 PSQI 총분개선우우대조조( P＜0.05)；치료조불량반응발생솔위8.33%，현저저우대조조적16.67%( P＜0.05)。결론오잡서평작위치료원발성삼차신경통적일선용약，진통효과가、림상료효우、불량반응솔저，차가유효개선환자수면질량，치득림상추엄。
Objective To evaluate the clinical efficacy and sleep quality improvement of oxcarbazepine in treatment of primary trigeminal neuralgia ( PTN ) . Methods 120 patients with PTN were randomly divided into 2 groups, 60 cases in each group. The treatment group took oxcarbazepine, while the control group adopted the carbamzepine treatment. The VAS, PSQI scores and occurrence rate of adverse reactions after 12-week treatment were evaluated. Results The total effective rate in the treatment group was 88. 33%, which was sig-nificantly higher than 76. 67% in the control group ( P < 0. 05 ); the sleep quality, falling asleep time, sleep efficiency, sleep disorder, hypnotic drugs, days activity disorder and PSQI scores in the two groups were decreased compared with before treatment ( P < 0. 05 );but the effects of the treatment group in the aspects of sleep quality, falling asleep time, sleep time, sleep efficiency, days activity disorder and PSQI scores were superior to the control group ( P < 0. 05 ); the occurrence rate of adverse reactions in the treatment group was 8. 33%, which was significantly lower than 16. 67% in the control group with statistical difference ( P < 0. 05 ) . Conclusion Oxcar-bazepine as the first line drug for treating PTN has good analgesic effect, excellent clinical efficacy and low occurrence rate of adverse reactions, moreover can effectively improve the sleep quality and is worthy of being popularized in clinic.