CAJ | 학술논문

目的：探讨声触诊组织定量技术（VirtualTouchTissueQuantification，VTQ）在乳腺良恶性结节鉴别诊断中的影响因素。方法对经手术或活检病理检查证实的92例乳腺结节患者行常规超声及VTQ检查，记录结节的常规超声图像特征、大小、深度及剪切波速度（ShearWaveVelocity， SWV）。采用受试者工作特征曲线分析VTQ技术对良恶性乳腺结节的鉴别诊断价值。采用多元逐步回归方法评估SWV值的可能影响因素，并以最大径2.0cm为界，评估不同亚组结节SWV值的影响因素。结果VTQ技术鉴别良恶性乳腺结节的灵敏性为90.0%，特异性为92.0%，准确性为80.2%，曲线下面积为0.917。病理性质及内部血流分级对全部结节及最大径＜2.0cm结节亚组的SWV值有影响，结节最大径线对最大径≥2.0cm亚组结节的SWV值有影响。结论VTQ技术为超声评估乳腺占位性病变提供了一种新方法。
목적：탐토성촉진조직정량기술（VirtualTouchTissueQuantification，VTQ）재유선량악성결절감별진단중적영향인소。방법대경수술혹활검병리검사증실적92례유선결절환자행상규초성급VTQ검사，기록결절적상규초성도상특정、대소、심도급전절파속도（ShearWaveVelocity， SWV）。채용수시자공작특정곡선분석VTQ기술대량악성유선결절적감별진단개치。채용다원축보회귀방법평고SWV치적가능영향인소，병이최대경2.0cm위계，평고불동아조결절SWV치적영향인소。결과VTQ기술감별량악성유선결절적령민성위90.0%，특이성위92.0%，준학성위80.2%，곡선하면적위0.917。병이성질급내부혈류분급대전부결절급최대경＜2.0cm결절아조적SWV치유영향，결절최대경선대최대경≥2.0cm아조결절적SWV치유영향。결론VTQ기술위초성평고유선점위성병변제공료일충신방법。
Objective To discuss the influence factors of VTQ (Virtual Touch Tissue Quantification) in differential diagnosis of benign and malignant breast nodules. Methods Ninety-two breast nodules patients who had been confirmed through surgeries or pathological tissue biopsies were examined by conventional ultrasound and VTQ so as to record the features of conventional ultrasound images as well as the size, depth and SWV (Shear Wave Velocity) of the nodules. The ROC (Receiver Operating Characteristic) curve was adopted to perform differential diagnosis of benign and malignant breast nodules. Moreover, the methodology of multiple stepwise regressions was also deployed to assess the potential influence factors of SWV values. And the maximum diameter of 2.0 cm was taken as a standard to assess the influence factors of SWV values for sub-group nodules. Results The sensitivity, specificity and accuracy of VTQ in differential diagnosis of benign and malignant breast nodules were 90.0%, 92.0% and 80.2% respectively; and the AUC (Area under Curve) was 0.917. The pathological nature and internal blood flow grading had influences on SWV value in the whole cases and nodules < 2.0 cm; while the maximum diameter standard of nodules had influences on the SWV value in the cases with sub-group nodules ≥ 2.0 cm. Conclusions VTQ provided a new method for differential diagnosis of breast nodules using ultrasonography.