CAJ | 학술논문

目的：观察磷酸西格列汀治疗早期糖尿病肾病（DN）的疗效。方法将105例2型糖尿病早期DN患者随机分为磷酸西格列汀组( A组)和阿卡波糖组( B组)。在使用胰岛素的基础上，A组（52例）口服磷酸西格列汀片，B组（53例）口服阿卡波糖片，疗程48周。观察2组治疗前后血压( BP )、空腹血糖( FPG )、糖化血红蛋白( HbA1C )、血清高敏C反应蛋白( hs－CRP )、尿白蛋白排泄率( UAER )的变化。结果2组患者FPG及HbA1C均显著下降，但在降低BP，hs－CRP，UAER方面，A组优于B组( P＜0.05)。结论磷酸西格列汀在降糖的同时，也能降低尿白蛋白排泄率，对治疗早期DN有效。
목적：관찰린산서격렬정치료조기당뇨병신병（DN）적료효。방법장105례2형당뇨병조기DN환자수궤분위린산서격렬정조( A조)화아잡파당조( B조)。재사용이도소적기출상，A조（52례）구복린산서격렬정편，B조（53례）구복아잡파당편，료정48주。관찰2조치료전후혈압( BP )、공복혈당( FPG )、당화혈홍단백( HbA1C )、혈청고민C반응단백( hs－CRP )、뇨백단백배설솔( UAER )적변화。결과2조환자FPG급HbA1C균현저하강，단재강저BP，hs－CRP，UAER방면，A조우우B조( P＜0.05)。결론린산서격렬정재강당적동시，야능강저뇨백단백배설솔，대치료조기DN유효。
Objective To observe the effect of sitagliptin phosphate in treating early diabetic nephropathy ( DN ) . Methods 105 patients with early diabetic nephropathy of type 2 diabetes mellitus ( T2DM ) were randomly divided into the sitagliptin phosphate group and the acarbose group. The sitagliptin phosphate group ( 52 cases ) was given oral Sitagliptin Phosphate Tablets, while the acarbose group ( 53 cases ) took oral Acarbose Tablets, the course of treatment was 48 weeks. The blood pressure ( BP ) , fasting plasma glucose ( FPG ) , glyco-sylated hemoglobin ( HbA1C ) , serum high sensitivity C-reactive protein ( hsCRP ) and change of urinary albumin excretion rate ( UAER ) before and after treatment were observed in the two groups. Results FPG and HbA1C in the two groups were significantly decreased. But the sitagliptin phosphate group was superior to the acarbose group in the aspects of reducing BP, hsCRP and UAER ( P < 0. 05 ) . Conclusion Sitagliptin phosphate decreases the glucose in T2DM patients with early DN, at the same time, also can reduce UAER and has the therapeutic effect on early DN.