CAJ | 학술논문

目的：探讨舌动脉超选择插管化学治疗栓塞在中晚期舌癌治疗中的价值。方法对11例临床 TNM分期为 T2～T4的舌鳞癌患者，从右股动脉超选择插管至舌动脉注入顺铂120 mg、盐酸博安霉素50 mg 及少量明胶海绵颗粒，3～4周后行手术切除，手术后行 DT 50 Gy 放射治疗。结果栓塞术后10 d 后，肿瘤均开始出现不同程度的缩小。术后出现中低度发热3例，轻度恶心4例，轻度呕吐1例。未发现骨髓抑制及肝肾功能损害等全身不良反应。根治性手术前评估肿瘤完全缓解2例，部分缓解9例，有效率100％；术中肿瘤均能完全切除，术后病理切片显示肿瘤组织内有明显坏死灶。术后随访1年，11例舌癌患者均未发现肿瘤复发或转移。结论对中晚期舌癌行舌动脉超选择插管化学治疗栓塞临床疗效好，不良反应少。
목적：탐토설동맥초선택삽관화학치료전새재중만기설암치료중적개치。방법대11례림상 TNM분기위 T2～T4적설린암환자，종우고동맥초선택삽관지설동맥주입순박120 mg、염산박안매소50 mg 급소량명효해면과립，3～4주후행수술절제，수술후행 DT 50 Gy 방사치료。결과전새술후10 d 후，종류균개시출현불동정도적축소。술후출현중저도발열3례，경도악심4례，경도구토1례。미발현골수억제급간신공능손해등전신불량반응。근치성수술전평고종류완전완해2례，부분완해9례，유효솔100％；술중종류균능완전절제，술후병리절편현시종류조직내유명현배사조。술후수방1년，11례설암환자균미발현종류복발혹전이。결론대중만기설암행설동맥초선택삽관화학치료전새림상료효호，불량반응소。
Objective To investigate the value of super-selective lingual arterial transcatheter chemo-embolization in the treatment of moderate and advanced tongue carcinoma.Methods Eleven patients were di-agnosed with T2 ~T4 tongue squamous cell cancer according to TNM staging.All patients were injected with cisplatin 120 mg,boanmycin hydrochloride 50 mg and a slight amount of gelatin sponge particles via super-se-lective catheterization from the lingual artery to the right femoral artery.Radical resection was performed 3 ~4 weeks later.Radiotherapy at a dosage of DT 50 Gy was conducted following surgery.Results At 10 d after chemoembolization,the tumor size was reduced to varying extent.Postoperatively,3 cases had mild and moder-ate fever,four with mild nausea and one with slight vomiting.No bone marrow suppression,hepatic and renal function injuries or alternative systemic adverse events were noted.Tumor evaluation before radical resection re-vealed that two patients had complete remission and nine partial remission with an effective rate of 100%.All tumors were completely resected intraoperatively.Postoperative pathological examination demonstrated that ap-parent necrotic lesions were found in the tumor tissues.Neither tumor recurrence nor metastasis was found after 1-year follow-up.Conclusion Super-selective lingual arterial transcatheter chemoembolization was a safe and effective treatment of moderate and advanced tongue cancer,yielding few adverse events.