CAJ | 학술논문

生长发育早期，促肾上腺皮质激素释放因子（CRF）可导致海马神经元突触功能发生改变，神经元树突棘形态结构重塑，最终损害海马记忆功能。CRFR1受体广泛存在于海马神经元树突棘头部突触后致密物（PSD）上，CRF 与 CRFR1受体结合，可通过 G 蛋白偶联受体介导的信号转导调控神经元突触相关功能，此外还可通过激活 RhoA-confilin 网络信号导致神经元树突棘形态结构发生改变。该文就树突棘形态结构、分子组成及相关调节蛋白以及 CRF 与海马相应功能区神经元树突棘作用等内容作一综述。
생장발육조기，촉신상선피질격소석방인자（CRF）가도치해마신경원돌촉공능발생개변，신경원수돌극형태결구중소，최종손해해마기억공능。CRFR1수체엄범존재우해마신경원수돌극두부돌촉후치밀물（PSD）상，CRF 여 CRFR1수체결합，가통과 G 단백우련수체개도적신호전도조공신경원돌촉상관공능，차외환가통과격활 RhoA-confilin 망락신호도치신경원수돌극형태결구발생개변。해문취수돌극형태결구、분자조성급상관조절단백이급 CRF 여해마상응공능구신경원수돌극작용등내용작일종술。
During the early stage of growth and development,corticotropin releasing factors (CRF) can alter the function of synapse of hippocampal neurons,remodel the morphology of neuronal dendritic spine and eventually damage the memory function of hippocampus.CRFR1 receptor is widely distributed in the posts-ynaptic dense materials (PSD)of dendritic spine head of hippocampal neurons.Binding of CRF and CRFR1 receptors not only could regulate the function of neuronal synapse via G-protein coupling receptor-mediated sig-naling transduction,but also cause morphological variations of neuronal dendritic spine through activating RhoA-confilin signaling network.This paper summarized the morphology,molecular composition and related regulatory proteins of dendritic spine and the effect of CRF upon neuronal dendritic spine in the corresponding domain of hippocampus,etc.