中国临床药理学杂志
中國臨床藥理學雜誌
중국림상약이학잡지
THE CHINESE JOURNAL OF CLINICAL PHARMACOLOGY
2015年
9期
686-688
,共3页
慢性肺源性心脏病%心力衰竭%川芎嗪注射液%酚妥拉明
慢性肺源性心髒病%心力衰竭%川芎嗪註射液%酚妥拉明
만성폐원성심장병%심력쇠갈%천궁진주사액%분타랍명
chronic pulmonaly%heart failure%ligustrazine injection%phentolamine
目的：评价川芎嗪注射液联合酚妥拉明治疗慢性肺源性心脏病心力衰竭的临床疗效及安全性。方法将78例慢性肺源性心脏病心力衰竭患者按照治疗方式随机地分为对照组38例与试验组40例。对照组给予抗生素抗感染，强心或者平喘、祛痰等治疗，试验组在对照组用药基础上给予甲磺酸酚妥拉明注射液10 mg，静脉滴注，每日2次，治疗10 d；盐酸川芎嗪注射液240 mg，静脉滴注，每日1次，治疗10 d。比较2组患者心功能分级改善情况、治疗前后心脏指数、肺动脉压力及血气指标水平变化情况。结果治疗后，试验组患者心功能分级情况显著优于对照组（P＜0.05）。2组治疗后心脏指数、氧气分压及氧饱和度水平均显著高于治疗前（P＜0.05，P＜0.01，P＜0.05），肺动脉压力及二氧化碳分压水平均显著低于治疗前（P＜0.05，P＜0.01），且2组间治疗后上述指标水平差异也均具有统计学意义（ P＜0.05）。结论川芎嗪注射液联合酚妥拉明在治疗慢性肺源性心脏病心力衰竭的临床疗效显著，心功能分级改善明显。
目的：評價川芎嗪註射液聯閤酚妥拉明治療慢性肺源性心髒病心力衰竭的臨床療效及安全性。方法將78例慢性肺源性心髒病心力衰竭患者按照治療方式隨機地分為對照組38例與試驗組40例。對照組給予抗生素抗感染，彊心或者平喘、祛痰等治療，試驗組在對照組用藥基礎上給予甲磺痠酚妥拉明註射液10 mg，靜脈滴註，每日2次，治療10 d；鹽痠川芎嗪註射液240 mg，靜脈滴註，每日1次，治療10 d。比較2組患者心功能分級改善情況、治療前後心髒指數、肺動脈壓力及血氣指標水平變化情況。結果治療後，試驗組患者心功能分級情況顯著優于對照組（P＜0.05）。2組治療後心髒指數、氧氣分壓及氧飽和度水平均顯著高于治療前（P＜0.05，P＜0.01，P＜0.05），肺動脈壓力及二氧化碳分壓水平均顯著低于治療前（P＜0.05，P＜0.01），且2組間治療後上述指標水平差異也均具有統計學意義（ P＜0.05）。結論川芎嗪註射液聯閤酚妥拉明在治療慢性肺源性心髒病心力衰竭的臨床療效顯著，心功能分級改善明顯。
목적：평개천궁진주사액연합분타랍명치료만성폐원성심장병심력쇠갈적림상료효급안전성。방법장78례만성폐원성심장병심력쇠갈환자안조치료방식수궤지분위대조조38례여시험조40례。대조조급여항생소항감염，강심혹자평천、거담등치료，시험조재대조조용약기출상급여갑광산분타랍명주사액10 mg，정맥적주，매일2차，치료10 d；염산천궁진주사액240 mg，정맥적주，매일1차，치료10 d。비교2조환자심공능분급개선정황、치료전후심장지수、폐동맥압력급혈기지표수평변화정황。결과치료후，시험조환자심공능분급정황현저우우대조조（P＜0.05）。2조치료후심장지수、양기분압급양포화도수평균현저고우치료전（P＜0.05，P＜0.01，P＜0.05），폐동맥압력급이양화탄분압수평균현저저우치료전（P＜0.05，P＜0.01），차2조간치료후상술지표수평차이야균구유통계학의의（ P＜0.05）。결론천궁진주사액연합분타랍명재치료만성폐원성심장병심력쇠갈적림상료효현저，심공능분급개선명현。
Objective To explore the clinical effects of ligustrazine combined with phentolamine in the treatment of chronic pulmonary heart failure.Methods A total of 78 cases with chronic pulmonary heart failure were randomly divided into control group ( n=38) and experiment group ( n =40 ).The include 78 cases were all treated with general treatment such as antibiotics, eliminating phlegm and so on.And patients in the experiment group were given phentolamine 10 mg with 5%glucose 250 mL through intravenous drop infusion bid for 10 days plus ligustrazine 240 mg with 5%glucose 250 mL by intravenous drop infusion qd for 10 days on the basic treatment of control group.The data of clini-cal symptom improvement, CI, PASP and blood gas index were compared between the two group before and after treatment.Results After treat-ment, the heart function in the experiment group was significantly improved than control group ( P<0.05 ).The pulmonary function such as PASP, PaCO2 , PaO2 and SaO2 in the two groups were significantly improved in both groups ( P <0.05 ).Conclusion Ligustrazine combined with phentolamine can significantly improve the clinical efficacy of patients with chronic pulmonary heart failure, with significantly improved heart function.
