国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2015年
2期
112-114
,共3页
干细胞龛%造血干细胞%细胞因子类%信号传导
榦細胞龕%造血榦細胞%細胞因子類%信號傳導
간세포감%조혈간세포%세포인자류%신호전도
Stem cell niche%Hematopoietic stem cells%Cytokines%Signal transduction
造血微环境可通过释放可溶性调控因子,如细胞因子、趋化因子及黏附因子等促使造血干细胞(HSC)定位于造血微环境内,平衡HSC自我更新与分化状态,并使HSC维持相对稳态.可溶性调控因子可促使HSC黏附于造血微环境,这在HSC增殖与分化中发挥非常重要作用.笔者拟就目前参与HSC功能调控的可溶性调控因子及其所发挥的作用进行综述.
造血微環境可通過釋放可溶性調控因子,如細胞因子、趨化因子及黏附因子等促使造血榦細胞(HSC)定位于造血微環境內,平衡HSC自我更新與分化狀態,併使HSC維持相對穩態.可溶性調控因子可促使HSC黏附于造血微環境,這在HSC增殖與分化中髮揮非常重要作用.筆者擬就目前參與HSC功能調控的可溶性調控因子及其所髮揮的作用進行綜述.
조혈미배경가통과석방가용성조공인자,여세포인자、추화인자급점부인자등촉사조혈간세포(HSC)정위우조혈미배경내,평형HSC자아경신여분화상태,병사HSC유지상대은태.가용성조공인자가촉사HSC점부우조혈미배경,저재HSC증식여분화중발휘비상중요작용.필자의취목전삼여HSC공능조공적가용성조공인자급기소발휘적작용진행종술.
Hematopoietic microenvironment induces hematopoietic stem cell (HSC) to locate within hematopoietic microenvironment,balance self-renewal and differentiation state of HSC,and maintain a relatively stable state of HSC via soluble factors such as cytokines,chemokines and adhesion molecules.Soluble factors can keep HSC adhered to the hematopoietic mieroenvironment,which plays a vital role in the proliferation and differentiation of HSC.This article reviews literatures on the function of soluble regulatory factors which take part in the regulation of HSC.
