CAJ | 학술논문

白血病干细胞与白血病的发生、耐药及复发有关,要根除白血病,应考虑以白血病干细胞为治疗靶点.然而,白血病干细胞与正常造血干细胞具有很多相似特点,如何根除白血病干细胞而不影响正常造血干细胞的功能给研究者们提出了巨大挑战.近年研究发现,磷酸酯酶与张力蛋白同源物(PTEN)对造血干细胞与白血病干细胞的影响机制不同,这为白血病的靶向治疗带来机会.笔者拟就近年来有关PTEN对白血病干细胞及造血干细胞的影响机制及调节机制研究进行综述,旨在为白血病的靶向治疗提供新思路.
백혈병간세포여백혈병적발생、내약급복발유관,요근제백혈병,응고필이백혈병간세포위치료파점.연이,백혈병간세포여정상조혈간세포구유흔다상사특점,여하근제백혈병간세포이불영향정상조혈간세포적공능급연구자문제출료거대도전.근년연구발현,린산지매여장력단백동원물(PTEN)대조혈간세포여백혈병간세포적영향궤제불동,저위백혈병적파향치료대래궤회.필자의취근년래유관PTEN대백혈병간세포급조혈간세포적영향궤제급조절궤제연구진행종술,지재위백혈병적파향치료제공신사로.
Leukemia stem cells are considered responsible for the occurrence,prognosis,relapse and resistance to chemotherapy of leukemia.In order to completely eradicate leukemia cells and consequently cure the disease,leukemia stem cells therapies should be considered as a therapeutic target.However,the fact that leukemia stem cells share functional and phenotypic properties with normal hematopoietic stem cells poses a significant challenge to researchers:how to definitely eradicate leukemia stem cells without damaging normal hematopoietic stem cells and compromising hematopoiesis.In recent years,researchers found that phosphatase and tensin homolog (PTEN) regulates leukemia stem cells and hematopoietic stem cells through different mechanisms.And this discovery demonstrates that it is possible to identify pathways that differentially impact leukemia and normal stem cell function and opens new therapeutic perspectives for the selective elimination of leukemia stem cells.In this review,we briefly discuss the mechanisms that regulate PTEN function in leukemia stem cells and hematopoietic stem cells and their potential for the development of leukemia stem cells-targeted therapies.