国际输血及血液学杂志
國際輸血及血液學雜誌
국제수혈급혈액학잡지
INTERNATIONAL JOURNAL OF BLOOD TRANSFUSION AND HEMATOLOGY
2015年
2期
123-126
,共4页
抗药性,多药%干细胞,白血病%骨髓微环境
抗藥性,多藥%榦細胞,白血病%骨髓微環境
항약성,다약%간세포,백혈병%골수미배경
Drug resistance,multiple%Stem cells,leukemia%Bone marrow microenvironment
耐药是影响白血病患者预后和长期生存的主要因素之一.有效逆转白血病耐药,是提高和改善白血病患者预后和长期生存的重要途径之一.早期对白血病耐药机制的研究,主要集中于白血病细胞本身,如多药耐药基因等.随着对骨髓微环境的深入研究发现,在白血病耐药中,骨髓微环境对白血病细胞的保护作用起着重要作用,其影响机制主要为给白血病细胞提供存活或抗凋亡信号,并使白血病细胞处于相对静止状态.笔者拟就白血病耐药机制的研究概况进行综述,旨在为理解和探索逆转白血病耐药拓宽思路.
耐藥是影響白血病患者預後和長期生存的主要因素之一.有效逆轉白血病耐藥,是提高和改善白血病患者預後和長期生存的重要途徑之一.早期對白血病耐藥機製的研究,主要集中于白血病細胞本身,如多藥耐藥基因等.隨著對骨髓微環境的深入研究髮現,在白血病耐藥中,骨髓微環境對白血病細胞的保護作用起著重要作用,其影響機製主要為給白血病細胞提供存活或抗凋亡信號,併使白血病細胞處于相對靜止狀態.筆者擬就白血病耐藥機製的研究概況進行綜述,旨在為理解和探索逆轉白血病耐藥拓寬思路.
내약시영향백혈병환자예후화장기생존적주요인소지일.유효역전백혈병내약,시제고화개선백혈병환자예후화장기생존적중요도경지일.조기대백혈병내약궤제적연구,주요집중우백혈병세포본신,여다약내약기인등.수착대골수미배경적심입연구발현,재백혈병내약중,골수미배경대백혈병세포적보호작용기착중요작용,기영향궤제주요위급백혈병세포제공존활혹항조망신호,병사백혈병세포처우상대정지상태.필자의취백혈병내약궤제적연구개황진행종술,지재위리해화탐색역전백혈병내약탁관사로.
Drug resistance is the main factor that affect the prognosis of patients with leukemia and their long-term survival.Early studies about drug resistance in leukemia mainly focused on leukemia cells themselves (multi-resistant genes,etc.).With the in-depth study of the bone marrow microenvironment,researchers find that bone marrow microenvironment also plays an important role in the drug resistance of leukemia through providing leukemia cells survival or antiapoptotic signal and maintaining the leukemia cells in a relatively static state.Here we will review the research progress of drug resistance mechanism in leukemia,in order to grasp the leukemia drug resistance and reversal of leukemia drug resistance.
