CAJ | 학술논문

神经纤毛蛋白(NRP)是信号素(Sema)家族和血管内皮生长因子(VEGF)家族的共同受体.通过Sema家族和VEGF家族,NRP分别在神经元和心血管发育中起着重要作用.NRP通过与其配体的其他受体结合,形成复合体,如Sema家族的神经丛蛋白和VEGF家族的VEGF受体(VEGFR)2,进而加强其信号传导,从而调节一些生理过程,其中最重要的为胞迁移.研究证实,NRP在一些疾病病理相关过程中亦起着重要作用.NRP可高表达于多种肿瘤细胞,这提示NRP是肿瘤治疗的一个潜在靶点.此外,在免疫系统中,NRP通过Sema3A参与免疫负调节,为治疗自身免疫疾病提供新思路.笔者拟就NRP及其配体的免疫调节机制进行综述如下.
신경섬모단백(NRP)시신호소(Sema)가족화혈관내피생장인자(VEGF)가족적공동수체.통과Sema가족화VEGF가족,NRP분별재신경원화심혈관발육중기착중요작용.NRP통과여기배체적기타수체결합,형성복합체,여Sema가족적신경총단백화VEGF가족적VEGF수체(VEGFR)2,진이가강기신호전도,종이조절일사생리과정,기중최중요적위포천이.연구증실,NRP재일사질병병리상관과정중역기착중요작용.NRP가고표체우다충종류세포,저제시NRP시종류치료적일개잠재파점.차외,재면역계통중,NRP통과Sema3A삼여면역부조절,위치료자신면역질병제공신사로.필자의취NRP급기배체적면역조절궤제진행종술여하.
Neuropilins (NRP) are co-receptors for class 3 semaphorins (Sema) and members of the vascular endothelial growth factor (VEGF) family of angiogenic cytokines.Genetic analysis of the role of NRP in mice shows that NRP1 is essential for embryonic neuronal pathfinding and cardiovascular development,which is mediated via Sema and VEGF,respectively.NRP are thought to mediate functional responses,especially cell migration,as a result of complex formation with other receptors,such as plexins in the case of Sema and the VEGF receptor (VEGFR)2,resulting in enhanced signaling via some intracellular pathways.Recent findings indicate that NRP may play important biological roles in other physiological and disease-related processes.In particular,NRP are highly expressed in diverse tumour cell lines and human neoplasms.NRP also implicate in several biological processes regulating tumour growth in vivo,suggesting that NRP1 may be a future therapeutic target in cancer.In the immune system,NRP1 acts as a negative regulator of the immune system via Sema3A and it may be a therapeutic target in autoimmune diseases.In this article,we will review the immune regulatory mechanisms of NRP and its receptors.