CAJ | 학술논문

Zeste基因增强子人类同源物2(EZH2)基因作为多梳基因(PcG)家族中的核心成员，其在多种实体肿瘤中过度表达并与肿瘤的发生、发展、转移等生物学行为及预后有着密切的关系，但其具体机制仍知之甚少。笔者对EZH2作用机制的最新研究进展进行综述，其对揭示肿瘤发生发展过程，预测肿瘤的进展及预后，进而开发新的肿瘤靶向治疗药物具有较大的潜在临床价值。
Zeste기인증강자인류동원물2(EZH2)기인작위다소기인(PcG)가족중적핵심성원，기재다충실체종류중과도표체병여종류적발생、발전、전이등생물학행위급예후유착밀절적관계，단기구체궤제잉지지심소。필자대EZH2작용궤제적최신연구진전진행종술，기대게시종류발생발전과정，예측종류적진전급예후，진이개발신적종류파향치료약물구유교대적잠재림상개치。
As a core member of polycomb group genes family, Ebgabcer of zeste homolog 2 (EZH2) is over-expressed in many solid tumors and is closely related to carcinogenesis and deterioration, metastasis and prognosis of tumor. However, how EZH2 promotes tumor is still poorly understood. This review presents the concrete mechanisms and the correlation between EZH2 and tumor, which has great potential clinical value in predicting the development and the prognosis of tumor, and developing new molecular therapeutic target for cancer.