CAJ | 학술논문

人乳头瘤病毒(HPV)的持续感染已被证实是宫颈癌发生的必要因素。HPV病毒在感染机体的过程中，不仅可以诱导机体产生特异性的免疫应答，同时也可以逃避机体的免疫应答，从而使机体产生免疫耐受，最终导致宫颈癌的发生。有研究显示调节性T细胞(Treg)参与了病毒引起的免疫应答，它可以维持机体对病毒的免疫耐受，最终引起病毒持续感染。既往关于Treg细胞与宫颈癌发生的关系主要集中在外周血中Treg细胞相关的细胞因子，很少关注Treg细胞与HPV的关系，本文将对Treg 细胞与HPV存在状态的关系以及在HPV感染引起宫颈癌过程中的作用进行综述。
인유두류병독(HPV)적지속감염이피증실시궁경암발생적필요인소。HPV병독재감염궤체적과정중，불부가이유도궤체산생특이성적면역응답，동시야가이도피궤체적면역응답，종이사궤체산생면역내수，최종도치궁경암적발생。유연구현시조절성T세포(Treg)삼여료병독인기적면역응답，타가이유지궤체대병독적면역내수，최종인기병독지속감염。기왕관우Treg세포여궁경암발생적관계주요집중재외주혈중Treg세포상관적세포인자，흔소관주Treg세포여HPV적관계，본문장대Treg 세포여HPV존재상태적관계이급재HPV감염인기궁경암과정중적작용진행종술。
Persistent infection of human papilloma virus (HPV) has been proved to be a necessary cause of cervical cancer. During the infection process, HPV can not only induce specific immune response but also evade im-mune clean, which result in immune tolerance and eventually lead to the occurrence of cervical cancer. Increasing re-searches have shown that regulatory T cells (Treg) was involved in the immune response caused by virus. The Treg cells helped maintain the body's immune tolerance, which can eventually lead to persistent infection of the virus. Previ-ous researches about the correlation between Treg cells and cervical cancer focused mostly on the cytokines in periph-eral blood, while little attention was paid to the correlation between Treg cell and HPV. Therefore, interaction between Treg cell and HPV in different infection stages and the role of Treg cell in cervical cancer are reviewed in this paper.