海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2015年
10期
1418-1422
,共5页
ADPN基因%低骨量%骨密度%维吾尔族
ADPN基因%低骨量%骨密度%維吾爾族
ADPN기인%저골량%골밀도%유오이족
ADPN gene%Osteopenia%Bone mineral density%Uyghur
目的：研究ADPN基因2个单核苷酸多态性位点T45G (rs2241766)、G276T (rs1501299)与新疆维吾尔族老年人低骨量的相关性，探讨该基因多态性维吾尔族的分布差异。方法收集2010年以来入住新疆医科大学第一附属医院干部病房的维吾尔族患者共490例，使用双能X线骨密度仪测量腰椎或髋关节骨密度（BMD）值，根据BMD值进行分组，其中低骨量病例组(骨量减低组+骨质疏松组)250例，对照组(骨量正常组)240例。采用多重SNaPshot SNP方法对ADPN基因T45G及G276T位点进行基因分型。结果(1) ADPN基因多态性在病例组与对照组间整体进行比较，基因型及等位基因分布差异均无统计学意义(P>0.05)；(2) ADPN基因T45G、G276T两位点按性别分组，该基因多态性在男性、女性之间的分布差异无统计学意义(P>0.05)；(3) Logistic回归分析提示女性及高血压是影响骨质疏松的独立危险因素。结论 ADPN基因T45G、G276T多态性与新疆地区维吾尔族老年人群低骨量发生无明显相关性。
目的：研究ADPN基因2箇單覈苷痠多態性位點T45G (rs2241766)、G276T (rs1501299)與新疆維吾爾族老年人低骨量的相關性，探討該基因多態性維吾爾族的分佈差異。方法收集2010年以來入住新疆醫科大學第一附屬醫院榦部病房的維吾爾族患者共490例，使用雙能X線骨密度儀測量腰椎或髖關節骨密度（BMD）值，根據BMD值進行分組，其中低骨量病例組(骨量減低組+骨質疏鬆組)250例，對照組(骨量正常組)240例。採用多重SNaPshot SNP方法對ADPN基因T45G及G276T位點進行基因分型。結果(1) ADPN基因多態性在病例組與對照組間整體進行比較，基因型及等位基因分佈差異均無統計學意義(P>0.05)；(2) ADPN基因T45G、G276T兩位點按性彆分組，該基因多態性在男性、女性之間的分佈差異無統計學意義(P>0.05)；(3) Logistic迴歸分析提示女性及高血壓是影響骨質疏鬆的獨立危險因素。結論 ADPN基因T45G、G276T多態性與新疆地區維吾爾族老年人群低骨量髮生無明顯相關性。
목적：연구ADPN기인2개단핵감산다태성위점T45G (rs2241766)、G276T (rs1501299)여신강유오이족노년인저골량적상관성，탐토해기인다태성유오이족적분포차이。방법수집2010년이래입주신강의과대학제일부속의원간부병방적유오이족환자공490례，사용쌍능X선골밀도의측량요추혹관관절골밀도（BMD）치，근거BMD치진행분조，기중저골량병례조(골량감저조+골질소송조)250례，대조조(골량정상조)240례。채용다중SNaPshot SNP방법대ADPN기인T45G급G276T위점진행기인분형。결과(1) ADPN기인다태성재병례조여대조조간정체진행비교，기인형급등위기인분포차이균무통계학의의(P>0.05)；(2) ADPN기인T45G、G276T량위점안성별분조，해기인다태성재남성、녀성지간적분포차이무통계학의의(P>0.05)；(3) Logistic회귀분석제시녀성급고혈압시영향골질소송적독립위험인소。결론 ADPN기인T45G、G276T다태성여신강지구유오이족노년인군저골량발생무명현상관성。
Objective To study the correlation of polymorphisms of ADPN gene T45G (rs2241766) and G276T (rs1501299) with low bone mineral density in elderly Uyghur people in Xinjiang province, and to explore the distribution differences of polymorphisms of the gene in ethnic people. Methods A total of 490 elderly Uyghur pa-tients were selected from cadre wards of the First Affiliated Hospital of Xinjiang Medical University since 2010. Dual energy X-ray absorptiometry was used to detect bone mineral density (BMD) of lumbar spine and hip. All the patients were divided into the low BMD case group (with osteopenia and osteoporosis, 250 cases) and control group (normal BMD, 240 cases) according to the value of BMD. Genotype of ADPN T45G and G276T polymorphisms were done by multiplex SNaPshot reaction. Results (1) ADPN gene polymorphisms were compared between the low BMD case group and control group, which showed that there was no significant difference in the distribution of genotypes and al-leles (P>0.05). (2) The polymorphism of ADPN gene (T45G, G276T) showed no statistically significant difference in the distribution between male and female (P>0.05);(3) Logistic regression analysis showed that women and hyperten-sion were the independent risk factors for low osteoporosis. Conclusion ADPN gene (T45G, G276T) polymorphism showes no significant correlation with low bone mineral density in elderly Uyghur people in Xinjiang province.
