CAJ | 학술논문

从临床和DNA甲基化两方面报告含砷中药治疗骨髓增生异常综合征(MDS)研究进展.共经治患者千余例,总有效率80％左右;已有患者停止治疗1年以上,外周血象指标仍然全部正常;MDS的异常甲基化不仅表现为明显高甲基化,也表现为一些基因的低甲基化.疗效机制研究表明含砷中药治疗MDS对异常甲基化有双向调节作用,含砷中药治疗的主要作用机制是去甲基化,也可使部分低甲基化基因高甲基化.
종림상화DNA갑기화량방면보고함신중약치료골수증생이상종합정(MDS)연구진전.공경치환자천여례,총유효솔80％좌우;이유환자정지치료1년이상,외주혈상지표잉연전부정상;MDS적이상갑기화불부표현위명현고갑기화,야표현위일사기인적저갑기화.료효궤제연구표명함신중약치료MDS대이상갑기화유쌍향조절작용,함신중약치료적주요작용궤제시거갑기화,야가사부분저갑기화기인고갑기화.
This is a progress report on myelodysplastic syndromes (MDS) treatment with Chinese medicine containing arsenic in clinic and DNA methylation.Thousands of patients with MDS have been treated by Chinese medicine containing arsenic and 80 ％ total effective rate was got.A few of patients had discontinued the treatment more than one year and all of their blood indicators were normal level.Abnormal methylation in MDS appeared not only obvious hypermethylation but also hypomethylation of some genes.Our research revealed that the mechanism of Chinese medicine containing arsenic on MDS was a two-way regulation of DNA with main mechanism of demethylating and part mechanism of methylating.