CAJ | 학술논문

假基因是一类与编码基因高度相似但不能表达功能蛋白质的细胞内非编码基因，曾一度被认为是“化石基因”。随着人们对假基因调节功能的不断认识，假基因在恶性肿瘤发生发展中的作用逐渐得到了重视。本文从假基因对恶性肿瘤细胞生物学行为的影响方面对近年来的研究进行了回顾。一般认为，假基因可以通过其转录产物影响同源或非同源的编码基因表达，并通过多种机制调节肿瘤细胞生物学行为。假基因是否有其它影响肿瘤生物学行为的机制还有待研究。
가기인시일류여편마기인고도상사단불능표체공능단백질적세포내비편마기인，증일도피인위시“화석기인”。수착인문대가기인조절공능적불단인식，가기인재악성종류발생발전중적작용축점득도료중시。본문종가기인대악성종류세포생물학행위적영향방면대근년래적연구진행료회고。일반인위，가기인가이통과기전록산물영향동원혹비동원적편마기인표체，병통과다충궤제조절종류세포생물학행위。가기인시부유기타영향종류생물학행위적궤제환유대연구。
Pseudogenes are a kind of non-functional genes bearing close resemblance to the known genes at differ-ent loci,and were once considered as"genomic fossils". Nevertheless,the regulating function of pseudogenes has been uncovered,and the roles of pseudogenes in cancer are getting more attention. Here we focus on the effects of pseudo-genes on the tumor biological behavior. Generally,it is believed that pseudogene transcripts can regulate the expression of functional genes,and affect the biological behavior of tumor cells in multiple ways. The underlying mechanisms re-main to be further studied.