CAJ | 학술논문

目的：探讨pRb2/p130、CyclinD1蛋白和VEGF在正常子宫内膜、子宫内膜增殖症、非典型子宫内膜增殖症和子宫内膜癌中的表达、相关性及与临床病理特征的关系。方法：免疫组织化学EnVision二步法检测pRb2/p130、CyclinD1蛋白和VEGF在30例正常增生期子宫内膜、30例子宫内膜增殖症、40例非典型子宫内膜增殖症和68例子宫内膜癌中的表达。结果：在非典型子宫内膜增殖症中，VEGF的表达显著高于正常子宫内膜（ p﹤0.05），与CyclinD1呈正相关（ p＝0.013）。子宫内膜癌中，VEGF的表达分别与组织学分级、雌激素受体（ER）相关。VEGF 的表达显著高于子宫内膜增殖症（p﹤0.05），VEGF与pRb2/p130呈负相关（r＝-0.243，p＝0.045），分别与CyclinD1蛋白、ER呈正相关（r＝0.337，p＝0.005；r＝4.628，p＝0.031）。结论：pRb2/p130、CyclinD1蛋白和VEGF在非典型子宫内膜增殖症和子宫内膜癌中的异常表达，结合在一起可能成为癌前病变和子宫内膜癌侵袭的筛查指标。子宫内膜癌中，ER可能调控着VEGF的产生。
목적：탐토pRb2/p130、CyclinD1단백화VEGF재정상자궁내막、자궁내막증식증、비전형자궁내막증식증화자궁내막암중적표체、상관성급여림상병리특정적관계。방법：면역조직화학EnVision이보법검측pRb2/p130、CyclinD1단백화VEGF재30례정상증생기자궁내막、30례자궁내막증식증、40례비전형자궁내막증식증화68례자궁내막암중적표체。결과：재비전형자궁내막증식증중，VEGF적표체현저고우정상자궁내막（ p﹤0.05），여CyclinD1정정상관（ p＝0.013）。자궁내막암중，VEGF적표체분별여조직학분급、자격소수체（ER）상관。VEGF 적표체현저고우자궁내막증식증（p﹤0.05），VEGF여pRb2/p130정부상관（r＝-0.243，p＝0.045），분별여CyclinD1단백、ER정정상관（r＝0.337，p＝0.005；r＝4.628，p＝0.031）。결론：pRb2/p130、CyclinD1단백화VEGF재비전형자궁내막증식증화자궁내막암중적이상표체，결합재일기가능성위암전병변화자궁내막암침습적사사지표。자궁내막암중，ER가능조공착VEGF적산생。
Objective:To investigate the expressions of pRb2/p130,CyclinD1 protein and VEGF,their correlation and relationship with the pathological clinical features of normal endometrial tissue,endometrial hyperplasia,atypical endometrial hyperplasia and human endometrial carcinoma. Methods:Thirty normal endometrial tissue,30 endometrial hyperplasia,40 atypical endometrial hyperplasia and 68 endometrial carcinomas were collected. Immunohistochemistri-cal methods were used to detect their pRb2/p130,CycinD1 protein and VEGF expressions. Results:In the atypical endometrial hyperplasia,the expressions of VEGF were significantly higher than that of normal(p﹤0. 05). VEGF and CyclinD1 expression were positive correlated. In the endometrial carcinomas,the expression of VEGF was associated with tumor grade and ER. The expressions of VEGF were significantly higher than that of endometrial hyperplasia( p﹤0. 05). There was negative correlation between the expressions of pRb2/p130 protein and that of VEGF(r= -0. 243, p=0. 045). There was positive correlation between the expressions of CyclinD1 protein,ER and that of VEGF(r=0. 337,p=0. 005;r =4. 628,p =0. 031,respectively). Conclusion:The abnormal expression of pRb2/p130,Cy-clinD1 protein and VEGF in the atypical endometrial hyperplasia and that of endometrial carcinomas,combined to-gether,may be as screening index of precancerous lesions and endometrial cancer aggressiveness. Estrogen-receptor may be regulate production of VEGF.