现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2015年
11期
1562-1564
,共3页
赵卫东%兰永年%温小鹏%刘磊%任宏
趙衛東%蘭永年%溫小鵬%劉磊%任宏
조위동%란영년%온소붕%류뢰%임굉
替吉奥%胃癌%手术治疗
替吉奧%胃癌%手術治療
체길오%위암%수술치료
S-1%gastric cancer%surgical opertion
目的:观察可手术的胃癌患者术后替吉奥单药的临床应用及其效果。方法:以临床分期Ⅱ期及Ⅲ期胃癌患者,并经手术治疗后获得痊愈者为入选对象,术后1个月试验组给予替吉奥胶囊口服,用量为80mg/( m2·d),早晚分次口服,d1-14。对照组给于FOLFOX4标准方案,每2周作为一个周期,3周期后评价疗效。结果:试验组与对照组比较:在不良反应发生率、KPS评分级别、临床获益率、有效率、患者手术后2年生存率均无明显统计学差异。结论:胃癌手术后应用替吉奥单药控制,不良反应轻微,术后2年生存率与对照组相比无统计学差异,治疗依从性较好,值得推广应用。
目的:觀察可手術的胃癌患者術後替吉奧單藥的臨床應用及其效果。方法:以臨床分期Ⅱ期及Ⅲ期胃癌患者,併經手術治療後穫得痊愈者為入選對象,術後1箇月試驗組給予替吉奧膠囊口服,用量為80mg/( m2·d),早晚分次口服,d1-14。對照組給于FOLFOX4標準方案,每2週作為一箇週期,3週期後評價療效。結果:試驗組與對照組比較:在不良反應髮生率、KPS評分級彆、臨床穫益率、有效率、患者手術後2年生存率均無明顯統計學差異。結論:胃癌手術後應用替吉奧單藥控製,不良反應輕微,術後2年生存率與對照組相比無統計學差異,治療依從性較好,值得推廣應用。
목적:관찰가수술적위암환자술후체길오단약적림상응용급기효과。방법:이림상분기Ⅱ기급Ⅲ기위암환자,병경수술치료후획득전유자위입선대상,술후1개월시험조급여체길오효낭구복,용량위80mg/( m2·d),조만분차구복,d1-14。대조조급우FOLFOX4표준방안,매2주작위일개주기,3주기후평개료효。결과:시험조여대조조비교:재불량반응발생솔、KPS평분급별、림상획익솔、유효솔、환자수술후2년생존솔균무명현통계학차이。결론:위암수술후응용체길오단약공제,불량반응경미,술후2년생존솔여대조조상비무통계학차이,치료의종성교호,치득추엄응용。
Objective:To observe clinical application and results of patients with operable gastric cancer treated with S-1 monotherapy. Methods:Clinical stage Ⅱ and Ⅲ patients with gastric cancer,and after surgery to get healed were selected as objects,the test group was given S-1 after one month,with dosage of 80mg/(m2·d),divid-ed doses in morning and night,day 1-14 medication;Control group was given standard regimen:FOLFOX4,every two weeks as a period. Finally,two groups were evaluated after 3 cycles. Results:In two groups,incidence of adverse reac-tions,KPS score level,clinical benefit rate,efficient rate,2-year survival rate of patients after surgery,were no signif-icant statistical difference. Conclusion:For gastric cancer patients after surgery with S-1 single drug treatment,ad-verse reactions are mild,and there were no significant difference between the test group and the control group on 2-year survival rate,and treatment compliance.